Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Recent advances in developing photonic technologies using various materials offer enhanced biosensing, therapeutic intervention, and non‐invasive imaging healthcare. Here, this article summarizes significant technological advancements materials, devices, bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, on‐skin health monitoring. The details of required necessary properties, device configurations are described next‐generation followed by an explanation the working principles light‐based therapeutics diagnostics. Next, paper shares recent examples integrated systems focusing on translation immediate clinical studies. In addition, limitations existing devices future directions smart discussed. Collectively, review focus trends new nanomaterials, light delivery methods, system designs, mechanical structures, material functionalization, to advance digital

Language: Английский

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Dinuclear Dicationic Iridium Complexes for Highly Synergistic Photodynamic and Photothermal Therapy to Chemoresistant Cancer

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

A series of dinuclear Ir(III) complexes have been constructed for enhanced photodynamic and photothermal therapy (PDT PTT) cisplatin-resistant non-small-cell lung cancer. They enter cells via caveolar endocytosis, target mitochondria but not nuclear, generate both singlet oxygen superoxide anion, release heat when exposed to infrared (IR) irradiation, thus inducing reactive species (ROS)-associated cell disruption thermal ablation. The IR-generated ROS can further activate caspases, triggering apoptosis. Additionally, the deplete intracellular glutathione, lead lipid peroxidation, induce ferroptosis. selected complex

Language: Английский

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Thioketal-photocage: a universal modification strategy for constructing new photochemical tools for real-time imaging in living cells

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Glycosylated AIE‐active Red Light‐triggered Photocage with Precisely Tumor Targeting Capability for Synergistic Type I Photodynamic Therapy and CPT Chemotherapy

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 137(1)

Published: Sept. 13, 2024

Abstract Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near‐infrared light‐triggered photolysis process of current photocage largely singlet oxygen ( 1 O 2 )‐dependent lack compatibility with other reactive species (ROS)‐activated techniques, which has proven to be major bottleneck in achieving efficient precise treatment. Herein, we reported a lactosylated BT‐LRC by covalently incorporating camptothecin (CPT) into hybrid BODIPY‐TPE fluorophore via superoxide anion radical (O − ⋅)‐cleavable thioketal bond type I photodynamic therapy (PDT) anticancer drug release. Amphiphilic could self‐assembled aggregation‐induced emission (AIE)‐active nanoparticles (BT‐LRCs) owing regulation carbohydrate‐carbohydrate interactions (CCIs) among neighboring lactose units nanoaggregates. BT‐LRCs simultaneously generate abundant ⋅ through aggregation modulated interactions, DNA‐damaging agent CPT was subsequently effectively released. Notably, PDT chemotherapy collaboratively amplified therapeutic efficacy HepG2 cells tumor‐bearing mice. Furthermore, inherent AIE property endowed photocaged prodrug superior bioimaging capability, provided powerful tool real‐time tracking finely tuning photoactivated release behavior tumor therapy.

Language: Английский

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Glycosylated AIE‐active Red Light‐triggered Photocage with Precisely Tumor Targeting Capability for Synergistic Type I Photodynamic Therapy and CPT Chemotherapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Sept. 13, 2024

Photocaging is an emerging protocol for precisely manipulating spatial and temporal behaviors over biological activity. However, the red/near-infrared light-triggered photolysis process of current photocage largely singlet oxygen (

Language: Английский

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