Copper‐Based Nanozymes: Potential Therapies for Infectious Wounds

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Bacterial infections are a significant obstacle to the healing of acute and chronic wounds, such as diabetic ulcers burn injuries. Traditional antibiotics primary treatment for bacterial infections, but they present issues antibiotic resistance, limited efficacy, potential side effects. This challenge leads exploration nanozymes alternative therapeutic agents. Nanozymes nanomaterials with enzyme‐like activities. Owing their low production costs, high stability, scalability, multifunctionality, have emerged prominent focus in antimicrobial research. Among various types nanozymes, metal‐based offer several benefits, including broad‐spectrum activity robust catalytic properties. Specifically, copper‐based (CuNZs) shown considerable promoting wound healing. They exhibit strong effects, reduce inflammation, enhance tissue regeneration, making them highly advantageous use care. review describes dual functions CuNZs combating infection facilitating repair. Recent advancements design synthesis CuNZs, evaluating promotion, biosafety both vitro vivo on basis core components, critically important.

Language: Английский

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An emodin-mediated multifunctional nanoplatform with augmented sonodynamic and immunoregulation for osteomyelitis therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 684, P. 122 - 137

Published: Jan. 13, 2025

Language: Английский

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Photothermal antimicrobial guar gum hydrogel cross-linked by bioactive small molecule lysine for infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140328 - 140328

Published: Jan. 1, 2025

Language: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101553 - 101553

Published: Feb. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Language: Английский

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Impact of cuproptosis in gliomas pathogenesis with targeting options

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111394 - 111394

Published: Jan. 1, 2025

Language: Английский

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The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 562 - 562

Published: Feb. 24, 2025

Background/Objectives. Chronic wounds pose a substantial global healthcare burden exacerbated by aging populations and the increasing prevalence of conditions such as diabetes, peripheral vascular disease, venous insufficiency. Impaired physiological repair mechanisms, including angiogenesis, collagen synthesis, re-epithelialization, hinder healing process in chronic wounds. Many these processes are dependent on their interaction with copper. We hypothesized that targeted delivery copper ions to wound bed would enhance healing. Methods. Wound dressings impregnated oxide microparticles were designed ensure controlled release ions. The efficacy was evaluated using non-infected models, diabetic mouse models compared against control silver dressings. Outcome measures included closure rates, epidermal skin quality assessed histopathological examination, gene expression profiling. Clinical applications through diverse case studies trials involving management. Results. Copper significantly accelerated enhanced angiogenesis Histopathological analyses revealed faster granulation tissue formation, regeneration, neovascularization. Gene showed upregulation critical angiogenic factors VEGF HIF-1α. Investigations clinical observations corroborated improved across various types, Conclusions. is essential for healing, copper-impregnated provide promising solution By enhancing go beyond antimicrobial action, offering cost-effective innovative alternative conventional therapies. represent transformative advancement addressing challenges care.

Language: Английский

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CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Ternary carbides ZrxAlCx−1: Innovative sol-gel synthesis and their biomedical applications

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114275 - 114275

Published: March 1, 2025

Language: Английский

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SERS-based approaches in the investigation of bacterial metabolism, antibiotic resistance, and species identification

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 336, P. 126051 - 126051

Published: March 13, 2025

Language: Английский

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Accelerating Interface NIR‐Induced Charge Transfer Through Cu and Black Phosphorus Modifying G‐C₃N₄ for Rapid Healing of Staphylococcus aureus Infected Diabetic Ulcer Wounds

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Abstract Bacteria‐infected diabetic wounds seriously threaten the lives of patients because ulcer tissues are quite difficult to repair while bacteria infections deteriorate this course. Clinically used antibiotics cannot fulfil mission but introduce risk bacterial resistance simultaneously. Herein, a near‐infrared (NIR) light‐responsive composite hydrogel is developed for rapid eradication and healing Staphylococcus aureus ( S. )‐infected wounds. The incorporates copper (Cu)‐doped graphitic carbon nitride (g‐C 3 N 4 ) nanosheets combined with black phosphorus (BP) through electrostatic bonding π–π stacking interactions, uniformly dispersed within chitosan (CS) matrix crosslinked polyvinyl alcohol (PVA) (Cu‐CN/BP@Gel). Under NIR light irradiation, Cu‐doping accelerated hot electron flow improved photothermal effect. Additionally, built‐in electric field formed by Cu‐CN/BP interfacial inhibited recombination electron‐hole pairs, enhancing reactive oxygen species (ROS) generation. Then, Cu‐CN/BP@Gel can reach antibacterial rate 99.18% against . successful application in wound infection presents new method high blood sugar ROS environment.

Language: Английский

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