Intramolecular Charge Transfer‐Regulated Isomeric Covalent Organic Frameworks for Multiple Solvent‐Response DOI Open Access
Ke Shi, Yujin Chen,

Han Peng

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Stimulus-responsive covalent organic frameworks (COFs) own color-switching characteristics when exposed to external stimuli. However, the investigations on multiple solvent-responsive COFs remain a challenge due synthetic difficulties and uncontrollable charge transfer process toward various solvents. In this contribution, two novel isomeric with regulated intramolecular (ICT) by modulating distance between donor/acceptor linkage are synthesized. The as-prepared exhibited significantly distinct solvatochromic behaviors in water, acid, halogenated solvents, respectively. These functions attributed enhancement degrees of ICT hydrogen bond interactions, protonation halogen/π addition, employed as stimulation-responsive powder or ink, displaying excellent image data encryption performances. work can not only offer viewpoint for creation but also expand COFs' potential applications information anti-counterfeiting.

Language: Английский

Recent advance development in pillar[5]arene-based nanomaterials for cancer therapy DOI
Yu Dai, Wenqiang Yu,

Yu‐Shan Cheng

et al.

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this review, we summarize five different types of pillar[5]arene-based nanomaterials and their applications in chemotherapy, photodynamic therapy, photothermal multimodal synergistic therapy for tumors.

Language: Английский

Citations

0
In Situ NADH-Activated BODIPY-Based Macrocyclic Supramolecular Photosensitizer for Chemo-Photodynamic Synergistic Tumor Therapy DOI
Zhuo Lei,

Ya-Hui Song,

Yongjun Leng

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Photodynamic therapy (PDT) based on supramolecular assembly has been receiving wide attention due to its great potential application in clinical treatment. Herein, we report a photoelectron "reservoir" (SPR) constructed by tetracationic boron dipyrromethene (BODIPY)-based macrocycle (BBox·4Cl), doxorubicin (Dox), and tumor-targeted β-cyclodextrin-grafted hyaluronic acid (HACD). Upon irradiation, BBox·4Cl can situ catalyze nicotinamide adenine dinucleotide (NADH) continuously generate electrons inject into SPR, which further transfers oxygen, inducing highly efficient hydroxyl radical generation even under hypoxia. Synergistically, Dox SPR as "pump" be encapsulated transport photoelectrons between two BODIPY units, while HACD "sponge" enrich the electrostatic interaction concentrate them closer space, facilitates intramolecular intermolecular transfer, respectively, significantly enhances of radicals. Meanwhile, electron replenishment causes NADH depletion redox dysfunction, thereby accelerating apoptosis achieving effective synergistic tumor therapy.

Language: Английский

Citations

0
Pillararene based supramolecular nanoplatform for endoplasmic reticulum-targeting type I photodynamic and NO gas therapy DOI

Shaoqi Xie,

Chang Liu,

Yue Cao

et al.

Science China Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Language: Английский

Citations

0
Intramolecular Charge Transfer‐Regulated Isomeric Covalent Organic Frameworks for Multiple Solvent‐Response DOI Open Access
Ke Shi, Yujin Chen,

Han Peng

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Stimulus-responsive covalent organic frameworks (COFs) own color-switching characteristics when exposed to external stimuli. However, the investigations on multiple solvent-responsive COFs remain a challenge due synthetic difficulties and uncontrollable charge transfer process toward various solvents. In this contribution, two novel isomeric with regulated intramolecular (ICT) by modulating distance between donor/acceptor linkage are synthesized. The as-prepared exhibited significantly distinct solvatochromic behaviors in water, acid, halogenated solvents, respectively. These functions attributed enhancement degrees of ICT hydrogen bond interactions, protonation halogen/π addition, employed as stimulation-responsive powder or ink, displaying excellent image data encryption performances. work can not only offer viewpoint for creation but also expand COFs' potential applications information anti-counterfeiting.

Language: Английский

Citations

0