Metal-based immunogenic cell death inducers for cancer immunotherapy

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

Immunity‐Modulating Metal‐Based Nanomaterials for Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Abstract Cancer immunotherapy, which leverages the body's immune system to combat cancer, offers promise of lower toxicity and higher therapeutic efficacy compared conventional treatments. However, current immunotherapeutic approaches face significant challenges including variable patient response, immune‐related adverse events, high costs, underscoring urgent need for innovative strategies. Metal‐based nanomaterials have emerged as a promising avenue in cancer immunotherapy due their unique physicochemical properties immune‐regulating capabilities. Despite potential, concerns about toxicity, incomplete understanding modulation mechanisms, early‐stage design strategies hinder clinical translation. This review summarizes recent advancements metal‐based elucidates mechanisms by they enhance antitumor immunity responses, explores potential synergistic effects combining multiple metals. We also discuss key future perspectives application, aiming provide theoretical foundation development immunotherapies promote broader application treatment.

Language: Английский

Azido acetylated-glucosamine Schiff base copper complexes accumulate in cancer cells and induce apoptosis in vitro:High selective cytotoxicity against HepG-2 cells

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142348 - 142348

Published: April 1, 2025

Language: Английский