Science Progress, Journal Year: 2025, Volume and Issue: 108(1)

Published: Jan. 1, 2025

The synthesis and application of metal complexes 2-(4-nitrophenyl)-1H-benzimidazole, a significant heterocyclic compound, are rooted in the formation its mono Schiff base precursor, N-(4-nitrobenzyl) benzene-1,2-diamine. This precursor is synthesized via condensation o-phenylenediamine (OPD) with 4-nitrobenzaldehyde (NBA). involves nucleophilic attack OPD's amino groups on carbonyl carbon 4-nitrobenzaldehyde, resulting an imine linkage essential for subsequent cyclization reactions. Cyclization benzene-1,2-diamine (NBD) crucial step forming benzimidazole ring. compound's significance lies structural electronic properties, influenced by electron-withdrawing nitro group, making it valuable coordination chemistry, medicinal materials science. In 2-(4-nitrophenyl)-1H-benzimidazole (NBI) acts as ligand, stable transition metals that exhibit enhanced catalytic activity. These various processes, including organic transformations polymerization core common motif biologically active compounds. presence group can modulate biological activity, derivatives promising candidates antimicrobial, anticancer, antiviral agents. Research has also highlighted applications bases their fields. serve versatile intermediates compounds, while explored catalytic, anticancer properties. remains topic interest due to potential developing new pharmaceuticals. from critical process wide-ranging optimization reaction conditions exploration properties continue drive research this area, highlighting importance both fundamental applied sciences.

Language: Английский