iScience, Journal Year: 2024, Volume and Issue: 27(8), P. 110428 - 110428
Published: July 3, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Nov. 8, 2024
Abstract All cells are encapsulated by a lipid membrane that facilitates their interactions with the environment. How manage diverse mixtures of lipids, which dictate property and function, is experimentally challenging to address. Here, we present an approach tune minimize composition in bacterium Mycoplasma mycoides its derived ‘minimal cell’ (JCVI-Syn3A), revealing two-component lipidome can support life. Systematic reintroduction phospholipids different features demonstrates acyl chain diversity more important for growth than head group diversity. By tuning chirality, explore divide between Archaea rest life, showing ancestral lipidomes could have been heterochiral. However, these simple organisms, heterochirality leads impaired cellular fitness. Thus, our offers tunable minimal system fundamental lipidomic requirements thereby extending concept life from genome lipidome.
Language: Английский
Citations
5
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 494, P. 138441 - 138441
Published: April 29, 2025
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 24, 2023
Abstract All cells are encapsulated by a lipid membrane which facilitates the interaction between life and its environment. How exploits diverse mixtures of lipids that dictate property function has been experimentally challenging to address. We introduce an approach tune minimize lipidomes in Mycoplasma mycoides Minimal Cell (JCVI-Syn3A) revealing 2-component lipidome can support life. Systematically reintroducing phospholipid features demonstrated acyl chain diversity is more critical for growth than head group diversity. By tuning chirality, we explored divide Archaea rest life, showing ancestral could have heterochiral. Our offers tunable minimal system explore fundamental lipidomic requirements thereby extending concept from genome lipidome.
Language: Английский
Citations
5
Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 332, P. 113233 - 113233
Published: April 22, 2024
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 110 - 110
Published: Dec. 26, 2024
First believed to be a simple intermediary between the information encoded in deoxyribonucleic acid and that functionally displayed proteins, ribonucleic (RNA) is now known have many functions through its abundance intricate, ubiquitous, diverse, dynamic structure. About 70–90% of human genome transcribed into protein-coding noncoding RNAs as main determinants along with regulatory sequences cellular populational biological diversity. From nucleotide sequence or primary structure, Watson–Crick pairing self-folding secondary compaction via longer distance non-Watson–Crick interactions tertiary RNA other biopolymers quaternary metabolites biomolecules quinary structure plays critical role RNA’s lifecycle from transcription decay processes. In contrast success 3-dimensional protein prediction using AlphaFold, beyond structures remains challenging. However, approaches involving machine learning artificial intelligence, sequencing modifications, structural analyses at single-cell intact tissue levels, among others, provide an optimistic outlook for continued development refinement RNA-based applications. Here, we highlight those gene therapy.
Language: Английский
Citations
1
iScience, Journal Year: 2024, Volume and Issue: 27(8), P. 110428 - 110428
Published: July 3, 2024
Language: Английский
Citations
0