Biology of the Cell,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Lipids
are
crucial
for
various
cellular
functions.
Besides
the
storage
of
energy
equivalents,
these
include
forming
membrane
bilayers
and
serving
as
signaling
molecules.
While
significant
progress
has
been
made
in
comprehension
molecular
biology
lipids,
their
functions
cell
nucleus
remain
poorly
understood.
The
main
role
eukaryotic
is
to
provide
an
environment
regulation
chromatin
which
a
complex
DNA,
histones,
associated
proteins.
Recent
studies
suggest
that
nuclear
lipids
play
epigenetics.
Here,
we
discuss
experimental
methods
lipid‐chromatin
research,
including
biophysical,
structural,
approaches,
pointing
out
strengths
weaknesses.
We
take
view
have
far
more
widespread
impact
on
than
currently
acknowledged.
This
gap
mostly
due
existing
challenges
study
biology.
Several
new,
interdisciplinary
approaches
discussed
could
aid
elucidating
roles
gene
expression.
Aging,
Journal Year:
2024,
Volume and Issue:
16(22), P. 13436 - 13441
Published: Dec. 9, 2024
Aging
is
a
fundamental
driver
of
numerous
life-threatening
diseases,
significantly
compromising
cellular
structures
and
functions,
including
the
integrity
nucleus.
A
consistent
feature
aging
across
diverse
species
progressive
accumulation
lipid
droplets
(nLDs)
within
nuclear
compartment,
which
disrupts
architecture
functionality.
Notably,
accompanied
by
marked
increase
in
nLD
at
envelope.
Interventions
known
to
extend
lifespan,
such
as
caloric
restriction
reduced
insulin
signaling,
reduce
both
rate
size
nLDs.
The
triglyceride
lipase
ATGL-1,
localizes
envelope,
plays
critical
role
limiting
buildup
maintaining
balance,
especially
long-lived
mutant
worms.
These
findings
establish
excessive
deposition
key
hallmark
aging,
with
profound
implications
for
processes
chromatin
organization,
DNA
repair,
gene
regulation.
In
addition,
ATGL-1
emerges
promising
therapeutic
target
preserving
health,
extending
organismal
healthspan,
combating
age-related
disorders
driven
dysregulation.
Biology of the Cell,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 8, 2024
Abstract
Lipids
are
crucial
for
various
cellular
functions.
Besides
the
storage
of
energy
equivalents,
these
include
forming
membrane
bilayers
and
serving
as
signaling
molecules.
While
significant
progress
has
been
made
in
comprehension
molecular
biology
lipids,
their
functions
cell
nucleus
remain
poorly
understood.
The
main
role
eukaryotic
is
to
provide
an
environment
regulation
chromatin
which
a
complex
DNA,
histones,
associated
proteins.
Recent
studies
suggest
that
nuclear
lipids
play
epigenetics.
Here,
we
discuss
experimental
methods
lipid‐chromatin
research,
including
biophysical,
structural,
approaches,
pointing
out
strengths
weaknesses.
We
take
view
have
far
more
widespread
impact
on
than
currently
acknowledged.
This
gap
mostly
due
existing
challenges
study
biology.
Several
new,
interdisciplinary
approaches
discussed
could
aid
elucidating
roles
gene
expression.
