19F-NMR Probing of Ion-Induced Conformational Changes in Detergent-Solubilized and Nanodisc-Reconstituted NCX_Mj

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6909 - 6909

Published: June 24, 2024

Consecutive interactions of 3Na

Language: Английский

Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis

Human Molecular Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background Genetic variants associated with molecular traits that are also liability to glioma can provide causal evidence for the identification and prioritisation of drug targets. Methods We performed comprehensive two-sample Mendelian randomisation (Wald ratio and/or IVW) colocalisation analyses on glioma. Instrumentable (QTLs P < 5 × 10−8) were identified amongst 11 985 gene expression measures, 13 285 splicing isoforms 10 198 protein abundance derived from 15 brain regions. Glioma summary-level data was extracted a genome-wide association meta-analysis 12 496 cases 18 190 controls. Results found effect 22 (across genes/proteins) risk. Thirteen have been previously linked risk five novel; HBEGF (5q31.3) all [OR 1.36 (95%CI 1.19–1.55); = 4.41 10−6]; CEP192 (18p11.21) splice isoform glioblastoma 4.40 2.28–8.48); 9.78 10−4]; FAIM (3q22.3) 2.72–3.43; 1.03 10−5 1.09 10−5]; SLC8A1 (2p22.1) 0.37 0.24–0.56; 5.72 D2HGDH (2q37.3) 0.86 0.80–0.92); 5.94 10−6)]. Conclusions robust prioritising genes their products in research. Our results highlight importance alternative as mechanism gliomagenesis an avenue exploration

Language: Английский

Ionic signalling (beyond calcium) in the nervous system: Physiology and Pathophysiology

Cell Calcium, Journal Year: 2024, Volume and Issue: 125, P. 102984 - 102984

Published: Dec. 7, 2024

Language: Английский