The
rapid
increase
in
the
number
of
stimuli-responsive
polymers,
also
known
as
smart
has
significantly
advanced
their
applications
various
fields.
These
polymers
can
respond
to
multiple
stimuli,
such
temperature,
pH,
solvent,
ionic
strength,
light,
and
electrical
magnetic
fields,
making
them
highly
valuable
both
academic
industrial
sectors.
Recent
studies
have
focused
on
developing
hydrogels
with
self-healing
properties
that
autonomously
recover
structural
integrity
mechanical
after
damage.
hydrogels,
formed
through
dynamic
covalent
reactions,
exhibit
superior
biocompatibility,
responsiveness
particularly
pH
changes.
However,
conventional
are
limited
by
weak
brittle
nature.
To
address
this,
ionizable
moieties
within
polyelectrolytes
be
tuned
create
ionically
cross-linked
leveraging
natural
alginate,
chitosan,
hyaluronic
acid,
cellulose.
integration
liquids
into
these
enhances
conductivity,
positioning
significant
agents.
This
review
focuses
emerging
field
ionic-based
explores
potential
dermal
tissue
engineering.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 283 - 283
Published: Feb. 20, 2025
Psoriasis
is
a
chronic
inflammatory
disease
with
complex
pathogenesis,
influenced
by
various
factors
involving
environment,
genes,
and
immunity.
The
main
symptoms
of
psoriasis
include
erythema,
scales,
itching,
etc.
At
present,
therapeutic
drugs
for
are
continually
evolving
towards
enhancing
treatment
efficacy
reducing
side
effects.
Firstly,
the
pathogenesis
characteristics
were
summarized.
Then,
types
benefits
topical
therapy
introduced,
such
as
aspects
avoiding
systemic
toxic
effects,
first
pass
effect,
gastrointestinal
reactions
accelerating
onset
time
improving
its
efficacy,
compared
to
drugs.
In
case
methotrexate,
cyclosporin
A,
Janus
kinase
(JAK)
inhibitors,
phosphodiesterase-4
(PDE-4)
this
review
had
further
discussion
on
improvement
translation
these
molecules
from
in
clinical
practice.
To
augment
limitation
skin
permeability,
nanotechnology
novel
drug
delivery
system
including
nanomedicines,
hydrogels,
ionic
liquids,
microneedles
elaborated
management.
Also,
exploration
targeting
pathogenic
genes
through
small
interfering
RNA
(siRNA)
using
nanoparticles
liquids
(ILs)
great
significance
long-term
psoriasis.
Taken
together,
development
numerous
platforms
expected
achieve
enhanced
penetration,
precise
efficient
molecule
interference
(RNAi)
therapeutics
prospects.
The
rapid
increase
in
the
number
of
stimuli-responsive
polymers,
also
known
as
smart
has
significantly
advanced
their
applications
various
fields.
These
polymers
can
respond
to
multiple
stimuli,
such
temperature,
pH,
solvent,
ionic
strength,
light,
and
electrical
magnetic
fields,
making
them
highly
valuable
both
academic
industrial
sectors.
Recent
studies
have
focused
on
developing
hydrogels
with
self-healing
properties
that
autonomously
recover
structural
integrity
mechanical
after
damage.
hydrogels,
formed
through
dynamic
covalent
reactions,
exhibit
superior
biocompatibility,
responsiveness
particularly
pH
changes.
However,
conventional
are
limited
by
weak
brittle
nature.
To
address
this,
ionizable
moieties
within
polyelectrolytes
be
tuned
create
ionically
cross-linked
leveraging
natural
alginate,
chitosan,
hyaluronic
acid,
cellulose.
integration
liquids
into
these
enhances
conductivity,
positioning
significant
agents.
This
review
focuses
emerging
field
ionic-based
explores
potential
dermal
tissue
engineering.
