Chemical Engineering and Processing - Process Intensification, Journal Year: 2023, Volume and Issue: 194, P. 109602 - 109602
Published: Nov. 5, 2023
Language: Английский
Chemical Engineering Science, Journal Year: 2024, Volume and Issue: 293, P. 120027 - 120027
Published: March 18, 2024
Language: Английский
Citations
6
Journal of Molecular Liquids, Journal Year: 2023, Volume and Issue: 393, P. 123617 - 123617
Published: Nov. 23, 2023
Language: Английский
Citations
13
Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1367 - 1393
Published: Jan. 1, 2024
Microfluidic-enabled smart microcapsules as delivery systems from droplet fabrication to tailored and controlled release.
Language: Английский
Citations
4
Langmuir, Journal Year: 2024, Volume and Issue: 40(28), P. 14233 - 14244
Published: July 3, 2024
Hydrogel microspheres are biocompatible materials widely used in biological and medical fields. Emulsification stirring the commonly methods to prepare hydrogels. However, size distribution is considerably wide, monodispersity mechanical intensity poor, stable operation conditions comparatively narrow meet some sophisticated applications. In this paper, a T-shaped stepwise microchannel combined with simple side structure developed explore liquid-liquid dispersion mechanism, interfacial evolution behavior, satellite droplet formation mechanism separation, eventual successful synthesis of dextran hydrogel microspheres. The effect parameters on microsphere comprehensively studied. flow pattern condition range given, mathematical prediction models under three different regimes for prediction. Based operating conditions, microdroplet-based method UV light curing synthesize microsphere. highly uniform monodispersed good synthesized microfluidic platform. could be tuned from 50 300 μm capillary number 0.006-0.742. This work not only provides facile functional polymeric preparation but also offers important design guidelines development robust microreactor.
Language: Английский
Citations
4
Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(2)
Published: Feb. 1, 2025
The present study investigated experimentally the effect of electric field on droplet formation process in a co-flow microchannel. A silicone oil (viscosity 4.6 mPa · s) and an aqueous solution (mixture 52% w/w water–glycerol) were used as continuous dispersed phases, respectively, while applied voltage varied from 0 kV to 10 kV. It was found that both flow rates two phases affected process. When no utilized, size decreased with increasing phase rate time rate. applied, voltage. Three patterns, namely squeezing, dripping, jetting, identified. Under field, range where squeezing pattern appeared reduced. related Bond number ratio total exponents depended whether map coordinates also built.
Language: Английский
Citations
0
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Although oral delivery of therapeutic agents offers numerous benefits, its application is limited due to the digestive tract's harsh conditions (e.g., strong acidity and high osmolarity), which impair activity create challenges in achieving targeted release into intestine. Here, we present multicompartmental hydrogel microspheres equipped with a concentric oil layer significantly enhance drug efficiency for treating inflammatory bowel disease (IBD). These are created through utilization triple-emulsion droplets, featuring intermediate layers that distinctively separate two prepolymer phases, allowing us fine-tune composition each compartment tailored polymerization strategy. We demonstrate can protect encapsulated material by preventing exposure acidic environment stomach during process. Unlike aqueous core capsules, composed hydrogel, provides stability even under osmolarity stomach. By fine-tuning shell's composition, develop capsules selectively response gut's pH conditions. system's efficacy preserving anti-inflammatory activities 5-aminosalicylic acid (5-ASA) Lys-Pro-Val (KPV) maintaining their effects on colonic epithelial cell migration proliferation.
Language: Английский
Citations
0
Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(5)
Published: May 1, 2025
The nozzle structure is identified as a critical factor in controlling monodisperse droplet generation microfluidic step emulsification devices. Two groups of meticulously designed devices with distinct triangular nozzles are introduced this study to systematically investigate the hydrodynamic control by structure. Dripping and jetting regimes were characterized through regime diagrams, dripping optimal for producing highly droplets that insensitive flow rate variations. An opening angle 10° was determined design, significantly enhancing stability regime. In regime, duration confined-growing stage exhibits positive correlation volume ultimately determines resulting size. Furthermore, morphological evolution dispersed phase within demonstrated govern interfacial dynamics throughout entire cycle, closely associated Based on these insights, predictive model incorporating proposed estimate size under achieving reliable predictions maximum relative error 30%. These findings provide theoretical practical framework customizing applications, contributing enhanced precision efficiency generation.
Language: Английский
Citations
0
Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103532 - 103532
Published: May 2, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 356, P. 337 - 346
Published: March 9, 2023
Language: Английский
Citations
9
Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 326, P. 121603 - 121603
Published: Nov. 16, 2023
Language: Английский
Citations
9