Impact of the diseased lung microenvironment on the in vivo fate of inhaled particles DOI

Jiayi Gai,

Liu Liu, Xin Zhang

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 104019 - 104019

Published: May 8, 2024

Language: Английский

Nanozymes in cancer immunotherapy: metabolic disruption and therapeutic synergy DOI Creative Commons
X Xu, Yaowen Zhang,

Chijun Meng

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(37), P. 9111 - 9143

Published: Jan. 1, 2024

The unique roles of nanozymes in enhancing immunotherapy through disrupting tumor metabolism and mediating combination therapies.

Language: Английский

Citations

2
Biomedical Nanosystems for <i>in vivo</i> Detoxification: From Passive Delivery Systems to Functional Nanodevices and Nanorobots DOI Creative Commons
Tatiana N. Pashirova, Zukhra Shaihutdinova, В. Ф. Миронов

et al.

Acta Naturae, Journal Year: 2023, Volume and Issue: 15(1), P. 4 - 12

Published: May 3, 2023

The problem of low efficiency nanotherapeutic drugs challenges the creation new alternative biomedical nanosystems known as robotic nanodevices. In addition to encapsulating properties, nanodevices can perform different functions, such precision surgery, in vivo detection and imaging, biosensing, targeted delivery, and, more recently, detoxification endogenous xenobiotic compounds. Nanodevices for are aimed at removing toxic molecules from biological tissues, using a chemical- and/or enzyme-containing nanocarrier toxicant diffuse inside nanobody. This strategy is opposite drug delivery systems that focus on releasing them under influence external factors. review describes various kinds intended differ by type poisoning treatment they provide, well materials toxicants. final part devoted enzyme nanosystems, an emerging area research provides fast effective neutralization toxins vivo.

Language: Английский

Citations

5
Tumor Microenvironment Activated Multifunctional Nanoparticles for Precisely Controlled Tumor Photothermal and Photodynamic Therapy DOI
Ling Wang, Yu Chen,

Zhuoxue Han

et al.

Journal of Analysis and Testing, Journal Year: 2023, Volume and Issue: 7(3), P. 215 - 226

Published: Sept. 1, 2023

Language: Английский

Citations

4
Achieving deep intratumoral penetration and multimodal combined therapy for tumor through algal photosynthesis DOI Creative Commons
Xuwu Zhang, Xinyue Zhang, Shiqi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 6, 2024

Abstract Background Elevated interstitial fluid pressure within tumors, resulting from impaired lymphatic drainage, constitutes a critical barrier to effective drug penetration and therapeutic outcomes. Results In this study, based on the photosynthetic characteristics of algae, an active carrier (CP@ICG) derived Chlorella pyrenoidos (CP) was designed constructed. Leveraging hypoxia tropism phototropism exhibited by CP, we achieved targeted transport tumor sites. Additionally, dual near-infrared (NIR) irradiation at site facilitated photosynthesis in enabling breakdown excessive intratumoral generating oxygen water decomposition. This process effectively reduced pressure, thereby promoting enhanced perfusion blood into tumor, significantly improving deep-seated chemotherapeutic agents, alleviating hypoxia. Conclusions CP@ICG demonstrated combined effect photothermal/photodynamic/starvation therapy, exhibiting excellent vitro/in vivo anti-tumor efficacy favorable biocompatibility. work provides scientific foundation for application microbial-enhanced delivery therapy. Graphical

Language: Английский

Citations

1
Impact of the diseased lung microenvironment on the in vivo fate of inhaled particles DOI

Jiayi Gai,

Liu Liu, Xin Zhang

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 104019 - 104019

Published: May 8, 2024

Language: Английский

Citations

1