Hypoxia-Targeted-Therapy: Mussel-Inspired hollow polydopamine nanocarrier containing MoS2 nanozyme and Tirapazamine with Anti-Angiogenesis Property for synergistic tumor therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 396 - 414

Published: Jan. 20, 2025

Language: Английский

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Specific surface area (SSA) of perovskites with uncertainty estimation approach

Computational Materials Science, Journal Year: 2025, Volume and Issue: 249, P. 113668 - 113668

Published: Jan. 9, 2025

Language: Английский

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Metal/Covalent Organic Framework Encapsulated Lead-Free Halide Perovskite Hybrid Nanocatalysts: Multifunctional Applications, Design, Recent Trends, Challenges, and Prospects

ACS Omega, Journal Year: 2024, Volume and Issue: 9(32), P. 34220 - 34242

Published: Aug. 1, 2024

Perovskites are bringing revolutionization in a various fields due to their exceptional properties and crystalline structure. Most specifically, halide perovskites (HPs), lead-free (LFHPs), perovskite quantum dots (HPs QDs) becoming hotspots unique optoelectronic properties, low cost, simple processing. HPs QDs, particular, have excellent photovoltaic applications because of tunable emission, high photoluminescence yield (PLQY), effective charge separation, cost. However, practical the QDs family some limitations such as degradation, instability, deep trap states within bandgap, structural inflexibility, scalability, inconsistent reproducibility, environmental concerns, which can be covered by encapsulating into porous materials like metal–organic frameworks (MOFs) or covalent–organic (COFs) that offer protection, prevention aggregation, optical flexibility structure, enhanced biocompatibility, improved stability under harsh conditions, consistency production quality, efficient separation. These advantages MOFs-COFs help harness full potential for applications. This review mainly consists three parts. The first portion discusses perovskites, dots. In second portion, we explore MOFs COFs. third particular emphasis is given thorough evaluation development QDs@MOFs-COFs based comprehensive investigations next-generation intended diverse technological applications, CO2 conversion, pollutant hydrogen generation, batteries, gas sensing, solar cells. Finally, this will open new gateway synthesis perovskite-based

Language: Английский

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Strategic Assessment of Boron-Enriched Carbon Dots/Naproxen: Diagnostic, Toxicity, and In Vivo Therapeutic Evaluation

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(2), P. 801 - 812

Published: Jan. 13, 2024

Cancer is a significant global public health concern, ranking as the leading cause of mortality worldwide. This study thoroughly explores boron-doped carbon dots (B-CDs) through simple/rapid microwave-assisted approach and their versatile applications in cancer therapy. The result was highly uniform particles with an average diameter approximately 4 nm. B-CDs exhibited notable properties, including strong fluorescence quantum yield 33%. Colloid stability tests revealed robustness within pH range 6–12, NaCl concentrations up to 0.5 M, temperatures ranging from 30 60 °C. also delved into kinetics naproxen release drug delivery system. loading efficacy exceeded 55.56%. Under varying conditions, conformed Peppas–Sahlin model, demonstrating potential Naproxen-loaded CDs for delivery. In vitro cytotoxicity assessments, conducted using CCK-8 Assay flow cytometry, consistently indicated low toxicity cell viability exceeding 80%. An vivo test on female mice administered 20 mg/kg 31 days reversible histological changes liver kidneys, while pancreas remained unaffected. Importantly, did not impact mice's physical behavior, body weight, or survival. experiments targeting benzo(a)pyrene-induced fibrosarcoma demonstrated carriers treatment cancer. provides thorough comprehension synthesis therapy systems.

Language: Английский

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Unlocking the catalytic potential of tungsten carbide coordinated with 3d transition metals in oxygen electrochemistry

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154145 - 154145

Published: July 27, 2024

Language: Английский

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Current trends in gas-synergized phototherapy for improved antitumor theranostics

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 174, P. 1 - 25

Published: Dec. 12, 2023

Language: Английский

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Engineering H₂O₂ Self-Supplying Platform for Xdynamic Therapies via Ru–Cu Peroxide Nanocarrier: Tumor Microenvironment-Mediated Synergistic Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(19), P. 24172 - 24190

Published: April 30, 2024

Of the most common, hypoxia, overexpressed glutathione (GSH), and insufficient H2O2 concentration in tumor microenvironment (TME) are main barriers to advancment of reactive oxygen species (ROS) mediated Xdynamic therapies (X = photo, chemodynamic, chemo). Maximizing Fenton catalytic efficiency is crucial chemodynamic therapy (CDT), yet endogenous levels not sufficient attain better anticancer efficacy. Specifically, there a need amplify reactivity within tumors, leveraging unique attributes TME. Herein, for first time, we design RuxCu1–xO2–Ce6/CPT (RCpCCPT) nanoagent TME-mediated synergistic based on heterogeneous Ru–Cu peroxide nanodots (RuxCu1–xO2 NDs) chlorine e6 (Ce6), loaded with ROS-responsive thioketal (TK) linked-camptothecin (CPT). The NDs (RCp NDs, x 0.50) possess highest vacancy (OV) density, which grants them potential form massive Lewis's acid sites adsorption, while dispersibility targetability were improved via surface modification using hyaluronic (HA). In TME, RCpCCPT degrades, releasing H2O2, Ru2+/3+, Cu+/2+ ions, cooperatively facilitate hydroxyl radical (•OH) formation deactivate antioxidant GSH enzymes through cocatalytic loop, resulting excellent therapeutic Furthermore, when combined laser treatment, produces singlet (1O2) PDT, induces cell apoptosis at sites. Following ROS generation, TK linkage disrupted, up 92% CPT 48 h. vitro investigations showed that laser-treated caused 81.5% death from PDT/CDT chemotherapy (CT). cancer cells red-blue emission images taking in, allows fluorescence image-guided treatment. overall results show RCp more biocompatible have effectiveness vivo.

Language: Английский

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Three Dimension of Au-MnO2 Nanostructure as Agent of Synergistic Cancer Therapy: Chemo-/Photodynamic and Photothermal Approaches

Dalton Transactions, Journal Year: 2024, Volume and Issue: 53(27), P. 11368 - 11379

Published: Jan. 1, 2024

The design of multimodal cancer therapy was focused on reaching an efficient process and minimizing harmful effects patients.

Language: Английский

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A cascade nanosystem with “Triple-Linkage” effect for enhanced photothermal and activatable metal ion therapy for hepatocellular carcinoma

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 14, 2024

Abstract Due to the limitations of single-model tumor therapeutic strategies, multimodal combination therapy have become a more favorable option enhance efficacy by compensating for its deficiencies. However, in nanomaterial-based therapeutics tumors, exploiting synergistic interactions and cascade relationships materials achieve effective treatments is still great challenge. Based on this, we constructed nanoplatform with “triple-linkage” effect cleverly integrating polydopamine (PDA), silver nanoparticles (AgNPs), glucose oxidase (GOx) realize enhanced photothermal (PTT) activatable metal ion (MIT) hepatocellular carcinoma (HCC) treatment. First, non-radiative conversion PDA under light conditions was AgNPs, which directly efficiency PDA. In addition, GOx reduced synthesis cellular heat shock proteins interfering energy metabolism, thereby enhancing sensitivity PTT. On other hand, H 2 O , by-product GOx-catalyzed glucose, could be used as an activation source activate non-toxic AgNPs release cytotoxic Ag + achieving -mediated MIT. conclusion, this nanosystem achieved efficient PTT MIT HCC among PDA, GOx, providing novel idea design systems regulation. Graphical abstract

Language: Английский

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Research Progress of Halide Perovskite Nanocrystals in Biomedical Applications: A Review

Inorganics, Journal Year: 2025, Volume and Issue: 13(2), P. 55 - 55

Published: Feb. 13, 2025

Halide perovskite nanocrystals have rapidly emerged as a prominent research topic in materials science over the past decade owing to their exceptional optoelectronic properties and tunability. Their distinctive characteristics, including high light absorption coefficients, quantum yields, narrow-band emissions, low defect densities, adjustable chemical compositions sizes, position them highly promising candidates for applications devices, energy conversion units, other related systems. However, due toxicity instability of halide nanocrystals, widespread application biomedical field has been limited past. In recent years, numerous innovative coating strategies reported effectively enhance stability while confining toxic metal ions within layers, thereby significantly improving biocompatibility. This review provides comprehensive summary progress biomedicine. It covers biocompatibility, well coated biomedicine, with particular focus on unique advantages bioimaging sensing. Finally, we address unresolved issues challenges, such metabolic pathways final products vivo. We hope inspire researchers provide direction future studies.

Language: Английский

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