Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157451 - 157451
Published: Nov. 1, 2024
Language: Английский
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28942 - e28942
Published: March 31, 2024
Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) widely used clinic as therapy. PDT combined with ferroptosis-promoting been found to be a promising strategy improve anti-cancer efficacy. Fenton reaction ferroptosis can provide oxygen for PDT, and produce reactive species enhance ferroptosis. In this review, we briefly present the importance of treatment, mechanism ferroptosis, researches on induced synergistic effect cancer killing.
Language: Английский
Citations
11
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842
Published: Jan. 1, 2024
The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.
Language: Английский
Citations
8
Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102341 - 102341
Published: July 22, 2024
Language: Английский
Citations
6
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 30, 2024
Photodynamic and photothermal therapies are promising treatments for cancer, dermatological, ophthalmological conditions. However, photodynamic therapy (PDT) is less effective in oxygen-deficient tumor environments. Combining PDT with (PTT) can enhance oxygen supply treatment efficacy. Inorganic PTT agents pose toxicity risks, limiting their clinical use despite high performance. In this study, we developed a novel nanomedicine integrating an all-organic agent organic photosensitizer, creating colocalized nanoplatform to phototherapy efficacy cancer treatment. nanoparticles (NPs) were synthesized through thermal phase transition of chromophores, demonstrating superior properties photostability. Utilizing nanoplatform, devised 'Combi NPs' combined PDT–PTT nanomedicine. Tests on A549 cell lines have revealed that Combi NPs exhibit cytotoxicity induce apoptosis hypoxic conditions, outperforming PTT-only NPs. The show significant potential microenvironments, potentially mitigating long-term accumulation associated toxicity.
Language: Английский
Citations
6
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 23, 2024
Photodynamic therapy and ferroptosis induction have risen as vanguard oncological interventions, distinguished by their precision ability to target vulnerabilities in cancer cells. therapy's non-invasive profile selective cytotoxicity complement ferroptosis' unique mode of action, which exploits iron-dependent lipid peroxidation, offering a pathway overcome chemoresistance with lower systemic impact. The synergism between photodynamic is underscored the depletion glutathione peroxidase four inhibitions therapy-induced reactive oxygen species, amplifying peroxidation enhancing ferroptotic cell death. This synergy presents an opportunity refine treatment modulating redox homeostasis. Porphyrin-based nanoscale metal-organic frameworks hybrid structures exceptional properties. These can serve platform for integrating through carefully designed functions. nanostructures be engineered deliver multiple therapeutic modalities simultaneously, marking pivotal advance multimodal therapy. review synthesizes recent progress porphyrin-modified combined ferroptosis, delineating mechanisms that underlie synergistic effects context. It underscores potential porphyrin-based advanced nanocarriers oncology, propelling field toward more efficacious tailored treatments.
Language: Английский
Citations
5
Bioconjugate Chemistry, Journal Year: 2023, Volume and Issue: 34(12), P. 2155 - 2180
Published: Nov. 13, 2023
Porphyrins have been vastly explored and applied in many cutting-edge fields with plenty of encouraging achievements because their excellent properties. As important derivatives porphyrins, porphyrin-based amphiphiles (PBAs) not only maintain the advanced properties porphyrins (catalysis, imaging, energy transfer) but also possess self-assembly encapsulation capability aqueous solution. Accordingly, PBAs self-assembles had roles diagnosing treating tumors inflammation lesions vivo, limited to these. In this article, we introduce research progress PBAs, including constitution, structure design strategies, performances tumor lesion diagnosis treatments. On that basis, defects synthesized during application possible effective strategies overcome limitations are proposed. Finally, perspectives on exploration updated based our knowledge. We hope review will bring researchers from various domains insights about PBAs.
Language: Английский
Citations
11
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136891 - 136891
Published: Oct. 28, 2024
Language: Английский
Citations
4
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Lanthanide-doped upconversion luminescent nanoparticles (UCNPs) have garnered extensive attention due to their notable anti-Stokes shifts and superior photostability. Notably, Ho3+-based UCNPs present a complex energy level configuration, which poses challenges in augmenting luminescence efficiency. Herein, rational design strategy was used enhance the intensity of Ho3+ ions by improving photon absorption ability utilization Efficient transfer excitation light were achieved through carefully selected host materials, precisely controlled sensitizers, external antennas using organic dyes, enhancing luminescence. Due attenuation effect hydroxyl vibration on luminescence, nanomaterials exhibit multicolor characteristics different solution environments. Significantly, composites intense red aqueous solution, showing great application potential biomedicine colorimetry.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 23, 2025
Abstract Photodynamic therapy (PDT) and photothermal (PTT) offer the advantages of precise temporal spatial selectivity in cancer treatment, minimizing damage to normal cells while effectively eliminating tumor cells. However, therapeutic efficacy phototherapy is always hindered by challenges such as hypoxia heat resistance. Herein, a pH‐responsive metal‐drug nanocomplex (denoted PAFH) comprising hypericin (HYP), apigenin (APG), polyvinylpyrrolidone (PVP), Fe 3+ developed enhance PDT PTT. The PAFH exhibits properties under 808 nm laser irradiation, which can disassociate response acidic microenvironment temperature increase induced PTT, thereby eventually triggering on‐site release APG HYP. released inhibits synthesis shock protein HSP‐90, facilitating PAFH‐mediated PTT kill at mild temperature. Additionally, alleviates then regulates expression hypoxia‐inducible factor HIF‐1𝛼, increasing cellular oxygen levels produce singlet for enhanced HYP‐mediated inhibiting metastasis. Ultimately, this sophisticated nanosystem represents an advanced strategy promote mitigating counteracting resistance, significantly improving therapy.
Language: Английский
Citations
0
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161356 - 161356
Published: March 1, 2025
Language: Английский
Citations
0