Cur@ZIF-8@BA nanomaterials with pH-responsive and photodynamic therapy properties promotes antimicrobial activity DOI Creative Commons

Xiu‐Juan Shang,

Hongdong Wang, Yongbo Yu

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: June 24, 2024

Antimicrobial photodynamic therapy (aPDT) has emerged as a highly promising strategy for non-antibiotic treatment of infections due to its unique advantages in efficient bactericidal action and reduction drug resistance. The natural photosensitizing properties curcumin (Cur) are widely acknowledged; however, limited bioavailability impeded practical application. In this study, we developed nanomaterial called Cur@ZIF-8@BA by encapsulating Cur within ZIF-8 modifying the surface with boric acid (BA). exhibits pH-responsive enhances bacterial binding, thereby effectively promoting therapy. Moreover, antibacterial activity against E. coli , Staphylococcus aureus A. baumannii is significantly increased presence light compared dark environment. mechanism behind may be that BA increases affinity towards bacteria, making released Zn 2+ from increase cell membrane permeability. This facilitates delivery into cells, resulting generation abundant reactive oxygen species (ROS) subsequent activity. conclusion, our prepared holds great promise photodynamically mediated antimicrobial strategy.

Language: Английский

Facile Synthesis of Copper Sulfide Nanoflower Decorated Amine-Grafted Polyacrylonitrile Fibers for Rapid and Long-Lasting Antimicrobial Performance Mediated by Photothermal and Photocatalytic Effects DOI
Qingyuan Li, Xin Pang, Xing Xing

et al.

Published: Jan. 1, 2025

Textiles due to its porous structure is a fitting environment for microbial growth, which will causing potential damage human daily life. Therefore, textile materials with rapid and long-lasting antimicrobial abilities are broadly needed in various scenarios. Copper sulfide (CuS) has been reported exhibit great photo-thermal catalytic properties can be used construct textiles. Herein, we prepared series of novel CuS nanoflower decorated amine-grafted polyacrylonitrile (APAN) textiles through two steps aqueous method where Cu ion was first chelate on fiber surface introduce sodium form an in-situ replacement. The morphology, structure, corresponding ability the obtained CuSNP-APAN were examined. optimal APAN/CuS (i.e. APAN/CuS100) achieved 99.99 % antibacterial efficiency against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) within 30 min 45 respectively under simulated sunlight irradiation. Even drug-resistant Methicillin-resistant (MRSA), modified showed extremely high rate (84.73 %) after 2 h contact, much higher than original APAN fibers as-prepared APAN/CuSO4 APAN/CuS50. 100-cycles washes, APAN/CuS100 still kept leaching Cu2+ 0.24 mg L-1. This study provides reliable approach photothermal bacterial deactivation, expand application fibers.

Language: Английский

Citations

0
Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases DOI
Xiang Wang, Zidong Wang, Siyuan Hu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540

Published: Jan. 22, 2025

Language: Английский

Citations

0
Peroxidase-like copper-doped carbon-dots embedded in hydrogels for stimuli-responsive bacterial biofilm elimination and wound healing DOI
Li Lin, Yuhui Wang, Sijung Hu

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Facile synthesis of copper sulfide nanoflower decorated amine-grafted polyacrylonitrile fibers for rapid and long-lasting antimicrobial performance mediated by photothermal and photocatalytic effects DOI
Qingyuan Li, Xin Pang, Xing Xing

et al.

Materials Today Communications, Journal Year: 2025, Volume and Issue: unknown, P. 112201 - 112201

Published: March 1, 2025

Language: Английский

Citations

0
Bioinspired Fe3O4@Ag@ indocyanine green/adenosine triphosphate nanoenzyme in synergistic antibacterial performance DOI Creative Commons
Dongmei Hu, Qing Wu,

Yujun Yang

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 25, 2025

Metal-based nanoenzymes with excellent biocompatibility and stable chemical properties are an effective antimicrobial agent against bacterial resistance due to their radical-mediated catalysis. In this work, the pH of most infection sites being close neutral, targeting problem Fe3O4@Ag difficulty in maintaining catalytic activity neutral environments, we prepare a novel multifunctional Fe3O4@Ag@ indocyanine green/adenosine triphosphate peroxidase for synergistic antibacterial activity. ICG (Indocyanine Green) ATP (Adenosine triphosphate) adsorbed on surface through electrostatic adsorption form its structure. The cell viability remained above 90%, indicating good biocompatibility. By complexing participate single electron transfer binding Fe (II), promotes sudden release hydroxyl radical (·OH) from system, successfully transferring extends pH. utilizing as photosensitizer sonosensitizer, under combined treatment near-infrared light ultrasound, photodynamic therapy (PDT)/photothermal (PTT)/sonodynamic (SDT) functions can be achieved, achieving effects. environment, bactericidal efficiency Gram negative (Escherichia coli) positive (Staphylococcus aureus) is 99.9% 99.7%, respectively, providing new multi-mode strategy infections.

Language: Английский

Citations

0
Photothermal-Boosted chemodynamic nanoplatforms via MXene Supported Pt Single-Atom catalysts for Synergistic MRSA eradication and infected wound Regeneration DOI

Xiaoshuai Sun,

Danyan Wang,

Shuai Ma

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162627 - 162627

Published: April 1, 2025

Language: Английский

Citations

0
Revolutionizing drug delivery: The power of stimulus-responsive nanoscale systems DOI
Shumeng Hu, Runan Zhao, Yue Shen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154265 - 154265

Published: July 24, 2024

Language: Английский

Citations

3
Double Enzyme Active Hydrogel Program Regulates the Microenvironment of Staphylococcus aureus‐Infected Pressure Ulcers DOI

Hailin Xie,

Yuna Qian,

Jiayi Ding

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

Abstract The treatment of infected pressure ulcers (IUPs) requires addressing diverse microenvironments. A pressing challenge is to effectively enhance the regenerative microenvironment at different stages healing process, tailoring interventions as needed. Here, a dual enzyme mimetic and bacterial responsive self‐activating antimicrobial hydrogel designed IPUs introduced. This incorporates pH‐responsive enzyme‐active nanoplatforms (HNTs‐Fe‐Ag) encapsulated within methacrylate‐modified silk fibroin (SFMA) dopamine methacrylamide (DMA) matrix. composite exhibits adaptive regulation capabilities. Under low pH infection, it has excellent activity by •OH generation in conjunction with photothermal effects. neutral alkaline chronic inflammation, catalyzes decomposition hydrogen peroxide (H 2 O ) produce oxygen (O ), thereby alleviating hypoxia scavenging reactive species (ROS), which turn remodulates phenotype macrophages. demonstrates on‐demand therapeutic effects wounds, significantly enhancing IUPs promoting wound closure, inflammation regulation, collagen deposition through self‐activated action during infection relief recovery. approach offers novel strategy for developing smart dressings.

Language: Английский

Citations

3
Facile synthesis of copper carbonate analog with peroxidase-like activity for colorimetric detection of isoniazid DOI Creative Commons
Yan Dai, Hao Zhang

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e34962 - e34962

Published: July 20, 2024

In this article, copper carbonate analog with good peroxidase-like activity was successfully synthesized for the first time

Language: Английский

Citations

2
Multi-omics analysis of Au@Pt nanozyme for the modulation of glucose and lipid metabolism DOI Creative Commons
Yanan Wang, Qi Zhang,

Minrui Kan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 31, 2024

Au@Pt nanozyme, a bimetallic core–shell structure Au and Pt nanoparticle, has attracted significant attention due to its excellent catalytic activity stability. Here, we propose that improves glucose tolerance reduces TG after four weeks administration. The transcriptomic analysis of mouse liver tissues treated with nanozyme showed changes in genes related lipid metabolism signaling pathways, including glycolysis/gluconeogenesis, pyruvate metabolism, PPAR signaling, insulin signaling. Moreover, fecal samples from mice the abundance beneficial gut microbiota such as Dubosiella, Parvibacter, Enterorhabdus, Monoglobus, Lachnospiraceae_UCG-008, Lachnospiraceae_UCG-006, Lachnospiraceae_UCG-001, Christensenellaceae_R-7_group. Combined multi-omics correlation analyses revealed modulation by was strongly correlated hepatic gene expression profiles well microbial profiles. Overall, our integrated demonstrated could modulate regulating key altering composition microbiota, providing new insights into potential applications treatment metabolic disorder.

Language: Английский

Citations

2