Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 126886 - 126886
Published: Sept. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 280, P. 135970 - 135970
Published: Sept. 26, 2024
Language: Английский
Citations
5
Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.
Language: Английский
Citations
0
Small Methods, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 26, 2025
Abstract The application of a multimodal combination therapy based on targeted nanodelivery system has been demonstrated to be more valuable in the treatment cancer. In this work, hollow polydopamine delivery (CCC@HP@M) was designed achieve sonodynamic and calcium‐overload combined for colon CCC@HP@M exhibits both homologous tumour‐targeting ability pH‐responsive drug release properties, enabling simultaneous CaO 2 nanoparticles/sonosensitizer Ce6/autophagy inhibitor CQ. nanoparticles as calcium agents capable triggering Ca 2+ overload tumor cells. oxidative stress produced by is facilitated disruption homeostasis enhance effect overload‐induced apoptosis. Furthermore, O augments sensitization therapy. autophagy CQ can inhibit protective cellular autophagy, which activated overload. Consequently, blockage ensure therapeutic ‐overload results experiments vitro vivo demonstrate that stimulus‐responsive achieves augmented This work offers promising theoretical basis optimizing strategies tumors clinical translational applications.
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract Focused ultrasound (FUS) has been widely adopted in medical and life science researches. Although various physical biological effects of FUS have well‐documented, there is still a lack understanding direct evidence on the mechanism therapeutic cell ablation caused by high‐intensity (HIFU) subsequent wound healing responses. This study develops an enclosed culture device that synergistically combines non‐invasive stimulation real‐time, on‐the‐fly live‐cell imaging, providing vitro platform to explore short long‐term ultrasound. The process, mechanism, response induced HIFU are elucidated, revealing unique termed ultrasound‐inflicted cellular mechanolysis, mediated growing subcellular cavitation air bubbles under confined contact with cells. provides previously unappreciated for biomechanical principles ultrasound‐based ablative therapy. A post‐ablation phantom layer also revealed serves as guiding cue collective migration during healing, thereby biomimetic model studying after HIFU‐inflicted damage. Together, this theoretical technological basis advancing therapy inspiring clinically relevant applications future.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141737 - 141737
Published: March 4, 2025
Language: Английский
Citations
0
Alexandria Engineering Journal, Journal Year: 2025, Volume and Issue: 122, P. 385 - 398
Published: March 18, 2025
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 13, 2025
Abstract Choriocarcinoma (CC) is a malignant solid tumor caused by abnormal differentiation of placental trophoblast cells. Clinical treatment mainly based on systemic intravenous chemotherapy, which faces multi therapeutic challenges. In this study, we pioneered the intrauterine perfusion route to treat orthotopic choriocarcinoma and achieved precise targeting effect combined with sonodynamic therapy (SDT). Our research meticulously developed an innovative biomimetic drug delivery system, designated as HIC@M nanoparticles (HIC@M NPs). This system involved incorporation cisplatin (CDDP) indocyanine green (ICG) onto hydrazide‐modified hyaluronic acid (HHA), followed encapsulation within cancer cell membrane. The prepared NPs could deplete GSH, generate large amounts reactive oxygen species (ROS), sensitize CDDP for higher efficiency. vivo results demonstrated that collaborative application SDT optimal efficacy while concurrently minimizing adverse effects. By depleting GSH generating ROS at site, not only modified microenvironment improve effectiveness mitigated resistance but also induced apoptosis ferroptosis activating p53 signaling pathway. conclusion, culminates in comprehensive anti‐tumor strategy choriocarcinoma.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 962 - 975
Published: Feb. 9, 2024
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 496, P. 154265 - 154265
Published: July 24, 2024
Language: Английский
Citations
3
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 491, P. 151773 - 151773
Published: May 7, 2024
Language: Английский
Citations
2