X-ray Triggered Scintillator Versatile Nanocatalytic Platform for Synergistic Photodynamic/Chemodynamic Therapy DOI
Bin Liu, Zongming Liu, Jinkai Li

et al.

Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 126886 - 126886

Published: Sept. 1, 2024

Language: Английский

Two-Dimensional Biodegradable l-Cysteine-Iodine Nanosheets for Computed Tomography-Guided Cancer Synergistic Sonodynamic Therapy and Chemotherapy DOI
Wenhao Dai, Haifeng Dong, Xueji Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(42), P. 56696 - 56704

Published: Oct. 8, 2024

Biodegradable versatile inorganic nanomaterials are highly desirable in the field of nanomedicine. Here, for first time, we report a kind novel two-dimensional biodegradable l-cysteine-iodine (l-Cys-I) nanosheet with high computed tomography (CT) imaging ability and sonosensitization efficacy. Such l-Cys-I nanosheets consist iodine molecules l-Cys, where coordinated stabilized by l-Cys cross-linked to form through disulfide bonds. The large convenient functional surface is further modified targeting moieties DSPE-PEG-RGD cancer drug doxorubicin (DOX) construct nanotheranostic nanoplatform (CIRD). Under ultrasound irradiation, CIRD assist tremendous reactive oxygen species generation controllable DOX release, leading remarkable anticancer performance both vitro vivo due synergistic sonodynamic therapy (SDT) chemotherapy. Our results validate that enable effective body excretion negligible systemic toxicity owing biodegradation properties. nanosheets, biodegradability, biocompatibility, versatility, hold great promise nanotheranostics.

Language: Английский

Citations

2
Delivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease DOI
Wenjing Wang, Zinan Zhao, Ziqiang Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 648 - 660

Published: Nov. 30, 2024

Language: Английский

Citations

2
Multi‐responsive co‐assembled polyurethane nanomicelles as anticancer drug delivery carriers DOI
Zhaoxia Liu, Lili Zhao,

Wangwang Tao

et al.

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: 141(34)

Published: June 6, 2024

Abstract In order to obtain a kind of anticancer drug delivery carriers with good stability in blood circulation, high cellular uptake, and controlled release ability, folate‐modified polyurethane disulfide bonds amino groups (FPUSN) carboxyl (PUC) were respectively synthesized. FPUSN PUC could co‐assemble water form nanomicelles (FPUSN/PUC) via electrostatic interaction. When the mass ratio was 12, FPUSN/PUC‐12 micelles had obvious negative‐to‐positive charge‐reversal property decreasing pH from 7.4 5.0. Doxorubicin‐loaded (FPUSN/PUC‐12@DOX) negative charges showed excellent under simulated normal physiological condition. However, happened at 6.5 positive increased decrease. glutathione concentration 10 mM, structure FPUSN/PUC‐12@DOX broken. So exhibited significant acid/reduction‐sensitive properties then DOX be rapidly released tumor intracellular environment. Cellular experimental results demonstrated that enhance uptake acid condition better anti‐proliferation effect against HGC‐27 cells than owing multi‐responsive synergistic effects. Therefore, FPUSN/PUC will have great application potential as for enhancing efficacy.

Language: Английский

Citations

1
Reactive oxygen species-responsive nanotherapy for the prevention and treatment of cerebral ischemia–reperfusion injury DOI
Jianglong Kong, Runxuan Chu,

Junjie Wen

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 153023 - 153023

Published: June 12, 2024

Language: Английский

Citations

1
X-ray Triggered Scintillator Versatile Nanocatalytic Platform for Synergistic Photodynamic/Chemodynamic Therapy DOI
Bin Liu, Zongming Liu, Jinkai Li

et al.

Talanta, Journal Year: 2024, Volume and Issue: unknown, P. 126886 - 126886

Published: Sept. 1, 2024

Language: Английский

Citations

1