ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(51), P. 70407 - 70418
Published: Dec. 13, 2024
Glioblastoma
multiforme
(GBM),
a
highly
prevalent
and
lethal
form
of
malignant
tumor,
is
typically
treated
with
Temozolomide
(TMZ),
chemotherapeutic
agent.
Nevertheless,
the
effectiveness
TMZ
hampered
by
inadequate
cell
entry,
systemic
adverse
effects,
monotherapy
constraints.
Previous
clinical
studies
have
demonstrated
that
combination
therapy
can
significantly
enhance
therapeutic
efficacy.
Herein,
we
developed
ultrasmall
virus-inspired
biodegradable
tetrasulfide-bridged
mesoporous
organosilica
coloaded
indocyanine
green
(ICG)
(designated
as
vMSTI)
for
fluorescence
imaging-guided
sonodynamic
chemotherapy
glutathione
(GSH)
depletion,
aiming
to
efficiency
GBM.
Once
accumulated
within
tumors,
vMSTI
nanosystem
efficiently
entered
tumor
cells
via
"spike
surface"-assisted
endocytosis.
Subsequently,
intracellular
overproduction
GSH
triggered
degradation
vMSTI,
resulting
in
release
both
ICG,
while
simultaneously
depleting
levels.
Upon
ultrasound
(US)
irradiation,
released
ICG
generated
abundant
reactive
oxygen
species
(ROS)
therapy,
which
could
be
further
potentiated
depletion.
Furthermore,
effectively
elicited
DNA
damage
enable
chemotherapy.
Consequently,
apoptosis,
suppressing
GBM
growth
under
guidance
imaging.
Our
nanosystems
offered
promising
strategy
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(33), P. 43364 - 43373
Published: Aug. 6, 2024
Calcium-overload-mediated
tumor
therapy
has
received
considerable
interest
in
oncology.
However,
its
efficacy
been
proven
to
be
inadequate
due
insufficient
calcium
ion
concentration
at
the
site
coupled
with
challenges
facilitating
efficient
uptake
by
tumors,
leading
unsatisfactory
therapeutic
outcomes.
In
present
study,
carbonate
nanoshell
mineralized
ferric
polydopamine
nanoparticles
(Fe-PDA@CaCO
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(2), P. 145 - 161
Published: Jan. 1, 2024
Aim:
This
study
aimed
to
develop
a
sonodynamic–chemodynamic
nanoparticle
functioning
on
glutathione
depletion
in
tumor
immunotherapy.
Materials
&
methods:
The
liposome-encapsulated
2,2-azobis[2-(2-imidazolin-2-yl)
propane]
dihydrochloride
(AIPH)
and
copper–cysteine
nanoparticles,
AIPH/Cu-Cys@Lipo,
were
synthesized
with
one-pot
method.
4T1
cells
injected
into
female
BALB/c
mice
for
modeling.
Results:
AIPH/Cu-Cys@Lipo
was
well
synthesized.
It
generated
alkyl
radicals
upon
ultrasound
stimulation.
promoted
the
generation
of
-OH
via
Fenton-like
reaction.
Both
vitro
vivo
experiments
verified
that
significantly
inhibited
development
by
decreasing
mitochondrial
membrane
potential,
activating
CD4+
CD8+
T
promoting
expression
IL-2
TNF-α.
Conclusion:
provides
high-quality
strategies
safe
effective
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 27, 2024
Abstract
Interest
in
therapies
that
influence
cell
senescence
to
regulate
cancer
is
increasing.
However,
the
understanding
of
prolonged
state
senescent
cells
and
interactions
involved
when
utilizing
promote
alongside
other
techniques
suppress
progression
limited.
This
study
introduces
an
innovative
artificial
nanozyme
named
MVPR,
constructed
from
vanadium
MXene
(Mo
4
VC
)
combined
with
cyclin‐dependent
kinase
inhibitors
Palbociclib
Arg‐Gly‐Asp,
for
precise
targeting
membranes.
Within
tumor
environment,
MVPR
initiates
a
cascade
catalytic
reactions,
boosting
glutathione
consumption,
generating
reactive
oxygen
species
(ROS).
When
damage
ROS
exceeds
cellular
repair
capabilities,
redox
balance
disrupted,
resulting
apoptosis.
Alternatively,
can
be
triggered
under
different
circumstances.
Senescent
impede
their
own
nearby
growth
by
releasing
cytokines,
thereby
effectively
curtail
uncontrolled
proliferation.
Furthermore,
immune
response
recruitment
evoked
metal
ions
together
enhance
immunotherapeutic
effect,
system
activity
augmenting
CD4
+
/CD8
T
Cancer
are
eliminated
through
actions
pro‐senescence,
enzyme
catalysis,
immunogenic
response.
proposes
pro‐senescence
strategy
anti‐tumor
therapy.
