ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70407 - 70418

Published: Dec. 13, 2024

Glioblastoma multiforme (GBM), a highly prevalent and lethal form of malignant tumor, is typically treated with Temozolomide (TMZ), chemotherapeutic agent. Nevertheless, the effectiveness TMZ hampered by inadequate cell entry, systemic adverse effects, monotherapy constraints. Previous clinical studies have demonstrated that combination therapy can significantly enhance therapeutic efficacy. Herein, we developed ultrasmall virus-inspired biodegradable tetrasulfide-bridged mesoporous organosilica coloaded indocyanine green (ICG) (designated as vMSTI) for fluorescence imaging-guided sonodynamic chemotherapy glutathione (GSH) depletion, aiming to efficiency GBM. Once accumulated within tumors, vMSTI nanosystem efficiently entered tumor cells via "spike surface"-assisted endocytosis. Subsequently, intracellular overproduction GSH triggered degradation vMSTI, resulting in release both ICG, while simultaneously depleting levels. Upon ultrasound (US) irradiation, released ICG generated abundant reactive oxygen species (ROS) therapy, which could be further potentiated depletion. Furthermore, effectively elicited DNA damage enable chemotherapy. Consequently, apoptosis, suppressing GBM growth under guidance imaging. Our nanosystems offered promising strategy

Language: Английский