In vivo self-assembled albumin nanoparticle elicit antitumor immunity of PD-1 inhibitor by imaging and clearing tumor-associated macrophages DOI Creative Commons
Yu Cheng,

Linan Hu,

Qilin Yu

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 3, 2024

Eliciting anti-tumor immune responses and improving the tumor microenvironment crucial for boosting effectiveness of anti-PD-1 immunotherapy. Tumor-associated macrophages (TAMs), primary types cells infiltrating tumors, play a critical role in formation an immunosuppressive microenvironment. In this study, we constructed novel Evans Blue (EB)-based

Language: Английский

Reduced graphene oxide quantum dots/manganese dioxide/glucose oxidase nanoparticles for cascade catalytic cancer treatment in multimodal starvation therapy-augmented chemodynamic/photothermal therapy DOI

Thejas P. Premji,

Banendu Sunder Dash,

Yu‐Jen Lu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114713 - 114713

Published: April 1, 2025

Language: Английский

Citations

0
Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications DOI

Guanghui Zhao,

Peng Tan,

Qi Tang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162723 - 162723

Published: April 1, 2025

Language: Английский

Citations

0
Cold Exposure Therapy Sensitizes Nanodrug-Mediated Radioimmunotherapy of Breast Cancer DOI
Kun Qiao, Pan You, Shiyuan Zhang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(43), P. 29689 - 29703

Published: Oct. 14, 2024

Cold exposure (CE) therapy can quickly induce tumor starvation by brown adipose tissue (BAT) thermogenesis. Exploring the combined antitumor mechanism of CE and traditional therapies (such as radiotherapy (RT)) is exciting promising. In this study, we investigated effect in combination with nitric oxide (NO) gas on sensitizing tumors to RT promoting radio-immunotherapy. We first constructed a liposome (SL) loaded NO prodrug S-nitroso-N-acetylpenicillamine (SNAP). When SL injected, glutathione (GSH) within region promotes release from SNAP. Subsequently, superoxide anion produced reacts generate peroxynitrite (ONOO–), which has strong oxidative properties induces cell death. Meanwhile, mice were exposed environment 4 °C. CE-mediated BAT thermogenesis induced starvation, led decrease ATP GSH content well an improvement hypoxic microenvironment myeloid-derived suppressor cells. All above have promoted effectiveness activated systemic immunity. bilateral experiment, treatment primary inhibited growth distant infiltration CD8+ T cells into tumor. These findings reveal that synergy CE, therapy, could confer high effective anticancer effects, providing possibilities personalized cancer treatment.

Language: Английский

Citations

3
Biomimetic Copper-Doped Polypyrrole Nanoparticles for Enhanced Cancer Low-Temperature Photothermal Therapy DOI Creative Commons
Hao Chen, Xi Luo, Wei Cai

et al.

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 7533 - 7541

Published: Dec. 1, 2023

Photothermal therapy (PTT) has a significant potential for its application in precision tumour therapy. However, PTT-induced hyperthermia may damage healthy tissues and trigger the expression of heat shock proteins (HSPs), thereby compromising long-term therapeutic efficacy PTT.In this study, biomimetic drug delivery system comprising CuP nanozymes as inner core platelet membrane (PM) outer shell was successfully developed administering synergistic chemodynamic mild PTT. PM is encapsulated on to form nanoparticle (PM-coated nanoparticles, PC). PC possesses peroxidase (POD) activity, can facilitate conversion hydrogen peroxide into ·OH, inhibiting HSPs.Upon exposure low-power laser irradiation (0.5 W/cm2, 1064 nm), convert near-infrared II energy energy, enabling administration enhanced In vitro vivo experiments have demonstrated that approach induce over 90% eradication with favourable biocompatibility.PC exhibits high biocompatibility, making it promising candidate future applications.

Language: Английский

Citations

8
Ruxolitinib-loaded cytokine nanosponge alleviated the cytokine storm and dampened macrophage overactivation for the treatment of hemophagocytic lymphohistiocytosis DOI
Honglan Wang, Yiwei Wang, Huiwen Liu

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 657, P. 124127 - 124127

Published: April 14, 2024

Language: Английский

Citations

2
Platelet-based bioactive systems guided precision targeting and immune regulation for cancer therapy DOI

Xinyi Cai,

Long Qiu,

Zhenying Diao

et al.

Nano Research, Journal Year: 2024, Volume and Issue: 17(9), P. 8269 - 8284

Published: June 26, 2024

Language: Английский

Citations

2
Platelet Membrane Biomimetic Manganese Carbonate Nanoparticles Promote Breast Cancer Stem Cell Clearance for Sensitized Radiotherapy DOI Creative Commons
Yi Jiang,

Xiaoming Liao,

Wei Tang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1699 - 1707

Published: Feb. 1, 2024

Introduction: The presence of cancer stem cells (CSCs) significantly limits the therapeutic efficacy radiotherapy (RT). Efficient elimination potential CSCs is crucial for enhancing effectiveness RT. Methods: In this study, we developed a biomimetic hybrid nano-system (PMC) composed MnCO 3 as inner core and platelet membrane (PM) outer shell. By exploiting specific recognition properties surface proteins, PMC enables precise targeting CSCs. Sonodynamic therapy (SDT) was employed using manganese carbonate nanoparticles (MnCO NPs), which generate abundant reactive oxygen species (ROS) upon ultrasound (US) irradiation, thereby impairing CSC self-renewal capacity eradicating Subsequent RT effectively eliminates common tumor cells. Results: Both in vitro cell experiments vivo animal studies demonstrate that SDT mediated by synergistically enhances to selectively combat while inhibiting growth without noticeable side effects. Discussion: Our findings offer novel insights safety profiles Keywords: clearance, radiosensitization, membrane, sonodynamic therapy,

Language: Английский

Citations

2
Augment of Ferroptosis with Photothermal Enhanced Fenton Reaction and Glutathione Inhibition for Tumor Synergistic Nano-Catalytic Therapy DOI Creative Commons
Qingcheng Song, Yiran Zhang, Hongzhi Hu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11923 - 11940

Published: Nov. 1, 2024

Ferroptosis-driven tumor ablation strategies based on nanotechnology could be achieved by elevating intracellular iron levels or inhibiting glutathione peroxidase 4 (GPX4) activity. However, the antioxidative defense mechanisms endow cells with ferroptosis resistance capacity. The purpose of this study was to develop a synergistic therapeutic platform enhance efficacy ferroptosis-based therapy. In study, multifunctional nano-catalytic (mFeB@PDA-FA) chemodynamic therapy (CDT) and photothermal (PTT) developed effectively trigger in tumor. our work, iron-based mesoporous Fe3O4 nanoparticles (mFe3O4 NPs) were employed for encapsulation L-buthionine sulfoximine (BSO), followed modification folic acid-functionalized polydopamine (PDA) coating periphery. Then, antitumor effect mFeB@PDA-FA NPs evaluated using Human OS (MNNG/HOS) subcutaneous xenograft model osteosarcoma. mFe3O4 harboring multivalent elements (Fe2+/3+) catalyze hydrogen peroxide (H2O2) into highly cytotoxic ˙OH, while microenvironment (TME)-responsive released BSO molecules inhibit biosynthesis GSH, thus achieving deactivation GPX4 enhancement ferroptosis. Moreover, thanks remarkable conversion performance PDA shell, PTT further synergistically enhanced CDT facilitated Both vivo vitro experiments confirmed that achieve excellent inhibition effects. nanotherapeutic disrupted redox homeostasis boosting through combination CDT, GSH elimination, which provided new perspective treatment sensitive tumors.

Language: Английский

Citations

2
Quercetin-loaded PLGA nanoparticles coating with macrophage membranes for targeted delivery in acute liver injury DOI

Jinlu Shang,

Tiantian Liang, Daiqing Wei

et al.

Nanotechnology, Journal Year: 2023, Volume and Issue: 35(11), P. 115102 - 115102

Published: Dec. 29, 2023

Abstract Quercetin (QU), a natural flavonoid with potent anti-inflammatory and antioxidant properties, holds promise in treating acute liver injury (ALI). Nonetheless, its limited solubility hampers efficacy, systemic distribution lacks targeting, leading to off-target effects. To address these challenges, we developed macrophage membrane-coated quercetin-loaded PLGA nanoparticles (MVs-QU-NPs) for active ALI targeting. The resulting MVs-QU-NPs exhibited spherical morphology clear core–shell structure. average size zeta potential were assessed as 141.70 ± 0.89 nm –31.83 0.76 mV, respectively. Further studies revealed sustained drug release characteristics from over continuous period of 24 h. Moreover, demonstrated excellent biocompatibility when tested on normal cells. results biodistribution analysis mice displayed the remarkable ALI-targeting ability MVs-DiD-NPs, highest fluorescence intensity observed tissue. This biomimetic approach combining membranes nanoparticle delivery, great targeted treatment.

Language: Английский

Citations

5
TME-Responsive Nanoplatform with Glutathione Depletion for Enhanced Tumor-Specific Mild Photothermal/Gene/Ferroptosis Synergistic Therapy DOI Creative Commons
Yuhang Tian, Xiang He,

Yanchi Yuan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9145 - 9160

Published: Sept. 1, 2024

Triple negative breast cancer (TNBC) is one of the worst prognosis types that urgently needs effective therapy methods. However, a complicated disease usually requires multiple treatment modalities.

Language: Английский

Citations

1