Targeted and Precise Drug Delivery Using a GSH-Responsive Ultra-Short Peptide-Based Injectable Hydrogel for Breast Cancer Cure
Satyajit Halder,
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Tanushree Das,
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Ritvika Kushwaha
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et al.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
An
ultra-short
peptide-based
injectable
hydrogel
delivers
doxorubicin
(DOX)
in
response
to
the
local
glutathione
(GSH).
A
single
injection
reduced
tumor
volume
by
approximately
75%
within
18
days
without
any
side
effects.
Language: Английский
Secondary Chemical Cross-Linking to Improve Mechanical Properties in a Multifaceted Biocompatible Strain Sensor
Ritvika Kushwaha,
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Souradeep Dey,
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Kanika Gupta
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et al.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(4), P. 5183 - 5195
Published: Jan. 18, 2024
A
new
conductive
and
transparent
organohydrogel
is
developed
with
high
stretchability,
excellent
mechanical,
self-healing,
antifreezing,
adhesive
properties.
simple
one-pot
polymerization
method
used
to
create
polyacrylamide
cross-linked
through
N,N′-methylenebis(acrylamide)
(MBAA)
divinylbenzene
(DVB).
The
dual
chemical
gel
network
complemented
by
several
physical
cross-links
via
hydrogen
bonding
π–π
interaction.
Multiple
are
construct
the
that
allows
toughness
(171
kPa),
low
modulus
(≈45
stretchability
(>1100%),
self-healing
ability.
use
of
appropriate
proportions
water/glycerol
binary
solvent
system
ensures
efficient
environment
tolerance
(−20
40
°C).
Phytic
acid
as
a
filler
provides
conductivity
contributes
cross-linking.
Dopamine
incorporated
in
matrix,
which
endows
property
gel.
organohydrogel-based
strain
sensors
state-independent
properties,
highly
linear
dependence,
antifatigue
performance
(>100
cycles).
Moreover,
during
practical
wearable
sensing
tests,
human
motions
can
be
detected,
including
speaking,
smiling,
joint
movement.
Additionally,
sensor
biocompatible,
indicating
potential
applications
for
next
generation
epidermal
sensors.
Language: Английский
Fabrication and characterization of responsible approach for targeted intestinal releasing and enhancing the effectivity of kidney tea saponin upon porous starch /xanthan gum /sodium alginate-based hydrogel bead
Muzi Yao,
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Jiahui Liu,
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Jia‐Ming Liu
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et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
279, P. 134974 - 134974
Published: Aug. 23, 2024
Language: Английский
In-Situ Fabricated Gold Nanostars on Hydrogel Beads as Photo-Oxidase Mimic for Rapid and Sustainable POCT of Uric Acid
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
Harnessing
the
photo-oxidase
like
activity
of
gold
nanostars
embedded
on
surface
hydrogel
macro-beads,
a
new
point-of-care
testing
platform
have
been
developed
for
accurate
measurement
uric
acid
in
bio-fluids.
Language: Английский