Advanced technology in neuroscience .,
Journal Year:
2024,
Volume and Issue:
1(2), P. 229 - 243
Published: Nov. 27, 2024
Peripheral
nerve
injury
is
a
worldwide
challenge
in
the
clinic.
Although
autologous
considered
gold
standard
for
bridging
large
defects
(>
5
mm),
donor-site
morbidity,
limited
sources
of
donor
nerves
and
other
potential
side
effects
restrict
its
application
regeneration.
Nerve
guidance
conduits
have
become
increasingly
popular
as
promising
alternative
to
repair
The
evolution
from
nondegradable
materials
various
biodegradable
subsequently
results
enhanced
properties,
such
superior
biodegradability,
mimetic
extracellular
matrix
an
optimal
structure.
This
review
describes
current
therapies
mechanism
with
advantages
limitations;
proposes
detailed
requirements
ideal
conduits;
emphasizes
applications
natural
polymers,
including
collagen,
chitosan,
alginate,
gelatin,
silk
fibroin
hyaluronic
acid,
regeneration
incorporation
functional
materials,
chemical
modifications
feasible
techniques
promote
cell
proliferation
axon
Compared
advanced
considerable
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101503 - 101503
Published: Feb. 6, 2025
Peripheral
nerve
injuries
are
a
prevalent
global
issue
that
has
garnered
great
concern.
Although
autografts
remain
the
preferred
clinical
approach
to
repair,
their
efficacy
is
hampered
by
factors
like
donor
scarcity.
The
emergence
of
guidance
conduits
as
novel
tissue
engineering
tools
offers
promising
alternative
strategy.
This
review
aims
interpret
and
commercialization
from
both
laboratory
perspectives.
To
enhance
comprehension
situations,
this
article
provides
comprehensive
analysis
approved
United
States
Food
Drug
Administration.
It
proposes
initial
six
months
post-transplantation
critical
window
period
for
evaluating
efficacy.
Additionally,
study
conducts
systematic
discussion
on
research
progress
conduits,
focusing
biomaterials
add-on
strategies
pivotal
regeneration,
supported
literature
analysis.
conduit
materials
prospective
optimal
thoroughly
discussed.
strategies,
together
with
distinct
obstacles
potentials
deeply
analyzed.
Based
above
evaluations,
development
path
manufacturing
strategy
envisioned.
conclusion
promoting
summarized
follows:
1)
optimization
fundamental
means;
2)
phased
application
additional
emphasized
direction;
3)
additive
techniques
necessary
tools.
As
result,
findings
provide
academic
practitioners
valuable
insights
may
facilitate
future
endeavors
conduits.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
With
the
rapid
development
of
materials
science
and
tissue
engineering,
a
variety
biomaterials
have
been
used
to
construct
engineering
scaffolds.
Due
performance
limitations
single
materials,
functional
composite
attracted
great
attention
as
tools
improve
effectiveness
biological
scaffolds
for
repair.
In
recent
years,
metal-organic
frameworks
(MOFs)
shown
promise
application
in
because
their
high
specific
surface
area,
porosity,
biocompatibility,
appropriate
environmental
sensitivities
other
advantages.
This
review
introduces
methods
construction
MOFs-based
describes
functions
mechanisms
MOFs
repairing
damaged
tissue.
The
latest
composites
applications
different
tissues
are
discussed.
Finally,
challenges
future
prospects
using
summarized.
aim
this
is
show
potential
field
stimulate
further
innovation
promising
area.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5376 - 5376
Published: Nov. 14, 2024
Tissue
engineering
of
nervous
tissue
is
a
promising
direction
in
the
treatment
neurological
diseases
such
as
spinal
cord
injuries
or
neuropathies.
Thanks
to
technological
progress
and
scientific
achievements;
use
cells;
artificial
scaffolds;
growth
factors
are
becoming
increasingly
common.
Despite
challenges
complex
structure
this
tissue,
regenerative
medicine
appears
future
approach
improve
quality
life
patients
with
injuries.
Until
now;
most
functional
biomaterials
used
for
purpose
were
based
on
decellularized
extra
cellular
matrix
(ECM)
nanofibrous
materials,
whereas
current
clinically
verified
ones
cases
do
not
exhibit
bioactivity
possibility
external
stimulation.
The
aim
research
was
develop
new
type
bioactive,
chitosan-based
3D
materials
applicable
nerve
guide
conduits
(NGCs)
modified
poly(dopamine),
Au/Pt
coated
PVP
nanoparticles,
cannabidiol.
NGCs
prepared
under
microwave-assisted
conditions
their
chemical
studied
using
FT-IR
method.
Next,
study
will
discuss
novel
morphology
swelling
abilities
well
susceptibility
biodegradation
presence
collagenase
lysozyme.
Finally,
potential
field
has
been
via
cytotoxicity
1321N1
human
astrocytoma
cell
line,
which
confirmed
biocompatibility
direct
contact
studies.
