Evolution of natural polymer nerve conduit technology in peripheral nerve repair: a narrative review DOI
Xiaopei Zhang, Lijie Yao, Yuying Yan

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 229 - 243

Published: Nov. 27, 2024

Peripheral nerve injury is a worldwide challenge in the clinic. Although autologous considered gold standard for bridging large defects (> 5 mm), donor-site morbidity, limited sources of donor nerves and other potential side effects restrict its application regeneration. Nerve guidance conduits have become increasingly popular as promising alternative to repair The evolution from nondegradable materials various biodegradable subsequently results enhanced properties, such superior biodegradability, mimetic extracellular matrix an optimal structure. This review describes current therapies mechanism with advantages limitations; proposes detailed requirements ideal conduits; emphasizes applications natural polymers, including collagen, chitosan, alginate, gelatin, silk fibroin hyaluronic acid, regeneration incorporation functional materials, chemical modifications feasible techniques promote cell proliferation axon Compared advanced considerable

Language: Английский

Evolution of natural polymer nerve conduit technology in peripheral nerve repair: a narrative review DOI
Xiaopei Zhang, Lijie Yao, Yuying Yan

et al.

Advanced technology in neuroscience ., Journal Year: 2024, Volume and Issue: 1(2), P. 229 - 243

Published: Nov. 27, 2024

Peripheral nerve injury is a worldwide challenge in the clinic. Although autologous considered gold standard for bridging large defects (> 5 mm), donor-site morbidity, limited sources of donor nerves and other potential side effects restrict its application regeneration. Nerve guidance conduits have become increasingly popular as promising alternative to repair The evolution from nondegradable materials various biodegradable subsequently results enhanced properties, such superior biodegradability, mimetic extracellular matrix an optimal structure. This review describes current therapies mechanism with advantages limitations; proposes detailed requirements ideal conduits; emphasizes applications natural polymers, including collagen, chitosan, alginate, gelatin, silk fibroin hyaluronic acid, regeneration incorporation functional materials, chemical modifications feasible techniques promote cell proliferation axon Compared advanced considerable

Language: Английский

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