International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
282, P. 137542 - 137542
Published: Nov. 12, 2024
The
rising
prevalence
of
global
antibiotic
resistance
evokes
the
urgent
requirement
to
explore
alternative
antimicrobial
candidates.
It
is
great
significance
overcome
these
serious
threats
multidrug-resistant
bacterial
infections
and
difficult-to-heal
cutaneous
wounds
human
health.
Herein,
we
proposed
a
rapidly
in
situ
forming
innovative
antibiotic-free
hydrogel
dressing
with
excellent
biocompatibility,
easy
injectability,
strong
tissue
adhesion
superior
antibacterial
activity
against
drug-resistant
bacteria.
An
octa-armed
poly(ethylene
glycol)
amine
(Octa-PEG-NH
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(7)
Published: May 21, 2024
The
antimicrobial
properties
of
copper
ions
can
reduce
the
overgrowth
microorganisms
to
a
certain
extent.
That
reduces
amount
antibiotics
used,
avoid
superbugs
and
potential
harm.
authors
reviewed
mechanisms
copper‐containing
nanoparticles
(NPs),
focusing
on
factors
influencing
their
properties.
They
concluded
that
were
better
in
environments
conducive
precipitation
exposure
microorganisms.
Comparing
with
other
metal
leads
question
why
is
such
an
important
ion.
In
recent
years,
development
science
technology
understanding
microscopic
world,
scientists
have
skillfully
applied
various
settings,
from
direct
contact
food
breeding
hygienic
environments,
confirmed
safety
application.
However,
because
toxic
effect
NPs,
future
goal
synthesize
NP
good
biocompatibility
antibacterial
efficiency
benefit
human
society.
Nanoscale Horizons,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
This
review
discusses
commonly
used
semiconductor
photocatalytic
antibacterial
materials,
methods
for
improving
their
photocatalysis
performance
and
application
bone
infection
treatment.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(4), P. 872 - 872
Published: Feb. 14, 2025
Bacterial
infections
are
one
of
the
major
problems
affecting
human
health,
which
is
exacerbated
by
increasing
antibiotic
resistance.
Antimicrobial
peptides
(AMPs)
an
ideal
alternative
to
antibiotics,
but
their
instability
and
toxicity
mammalian
cells
need
be
addressed.
Here,
black
phosphorus
nanosheets
(BPs)
were
successfully
decorated
with
melittin
(Mel),
a
kind
AMP,
through
electrostatic
interaction.
The
size
impacts
BPs
on
antibacterial
ability
biocompatibility
BPs/Mel
nanocomposites
studied
systematically.
Results
showed
that
made
from
middle-sized
(BPs/Mel-7)
have
strong
as
well
good
biocompatibility.
Moreover,
BPs/Mel-7
could
accelerate
skin
wound
healing
infected
Staphylococcus
aureus.
This
study
provides
facile
strategy
expand
application
AMPs.
The
increasing
prevalence
of
multidrug-resistant
bacteria
is
a
significant
global
health
threat.
In
contrast
to
conventional
antibiotic
treatments,
photodynamic
therapy
(PDT)
offers
promising
alternative
by
reducing
the
bacterial
adaptability
antibiotics
and
bactericides.
However,
traditional
photosensitizers
encounter
poor
antimicrobial
efficacy
due
hydrophilicity
photosensitizers,
short
lifespan,
narrow
diffusion
radius
reactive
oxygen
species
(ROS),
risk
exacerbating
inflammation.
this
study,
we
report
bacterial-targeting
supramolecular
nanophotosensitizer
for
combating
multidrug
resistant
bacteria.
nanophotosensitizer,
formed
through
host–guest
interactions
self-assembly
tetra-cyclodextrin-modified
silver
porphyrin
(AgTPP-CD4),
adamantyl-modified
phenylboronic
acid
(Ad-PBA),
curcumin
(Cur),
can
effectively
target
kill
methicillin-resistant
Staphylococcus
aureus
(MRSA).
Moreover,
it
reduces
inflammation
promotes
wound
healing
in
MRSA-infected
wounds
without
inducing
drug
resistance.
combination
chemistry
targeted
PDT
strategy
infections.
Chemistry of Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Covalent
organic
frameworks
(COFs)
have
recently
demonstrated
significant
potential
for
photocatalysis.
Optimizing
the
local
electronic
environment
in
COFs
has
been
considered
to
be
critical
enhancing
photocatalytic
activity.
Here,
we
report
a
one-pot
"grafting-to"
strategy
reprogram
configurations
of
series
isoreticular
multicomponent
by
introducing
electron-donating
or
electron-withdrawing
groups
into
pores
transform
photoinert
photoactive
and
form
intramolecular
donor–acceptor
(D-A)
structures.
Such
D-A
structures
enhanced
overall
hydrogen
peroxide
photoproduction
facilitating
charge
carrier
separation
optimizing
band
achieve
oxygen
reduction
reaction
water
oxidation
simultaneously.
Notably,
one
incorporated
with
2-aminothiazole
exhibits
production
rate
3701
μmol
g–1
h–1
solar-to-chemical
conversion
efficiency
0.13%
without
use
any
sacrificial
reagents,
it
100%
bacterial
killing
rates
remarkable
>90%
biofilm
removal
capability.
This
COF
modification
strategy,
which
not
reported
before,
offers
unique
approach
constructing
highly
active
photocatalysts
containing
great
future
design
antibacterial
therapies.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 6, 2025
Microbial
keratitis,
a
sight-threatening
corneal
infection,
remains
significant
global
health
concern.
Conventional
therapies
using
antimicrobial
agents
often
suffers
from
limitations
such
as
poor
drug
penetration,
side
effects,
and
occurrence
of
resistance,
with
prognosis.
Novel
treatment
techniques,
their
unique
properties
targeted
delivery
capabilities,
offers
promising
solution
to
overcome
these
challenges.
This
review
delves
into
timely
update
the
state-of-the-art
advance
therapeutics
for
keratitis
treatment.
The
diverse
microbial
origins
including
viral,
bacterial,
fungal
infections,
exploring
complex
pathogenic
mechanisms,
followed
by
resistance
mechanisms
in
pathogens
are
reviewed
briefly.
Importantly,
emerging
therapeutic
techniques
piezodynamic
therapy,
photothermal
photodynamic
nanoenzyme
metal
ion
therapy
summarized
this
showcasing
potential
traditional
treatments.
challenges
future
directions
nanotechnology-based
approaches
discussed,
focusing
on
safety,
targeting
strategies,
combination
therapies.
aims
inspire
researchers
revolutionize
accelerate
development
functional
materials
different
