Innovations in Biosensor Technologies for Healthcare Diagnostics and Therapeutic Drug Monitoring: Applications, Recent Progress, and Future Research Challenges

Sensors, Journal Year: 2024, Volume and Issue: 24(16), P. 5143 - 5143

Published: Aug. 8, 2024

This comprehensive review delves into the forefront of biosensor technologies and their critical roles in disease biomarker detection therapeutic drug monitoring. It provides an in-depth analysis various types applications, including enzymatic sensors, immunosensors, DNA elucidating mechanisms specific healthcare applications. The highlights recent innovations such as integrating nanotechnology, developing wearable devices, trends miniaturisation, showcasing transformative potential healthcare. In addition, it addresses significant sensitivity, specificity, reproducibility, data security challenges, proposing strategic solutions to overcome these obstacles. is envisaged that will inform decision-making, drive technological innovation, enhance global outcomes by synthesising multidisciplinary insights.

Language: Английский

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Artificial intelligence assisted label-free surface-enhanced Raman scattering detection of early-stage cancer-derived exosomes based on g-C3N4/Ag hybrid substrate prepared by electro-synthesis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155526 - 155526

Published: Sept. 6, 2024

Language: Английский

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Hydrogel-based 3D printing technology: From interfacial engineering to precision medicine

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 341, P. 103481 - 103481

Published: March 19, 2025

Language: Английский

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Entropy-driven DNA circuit induced rolling circle transcription generates fluorescent light-up RNA aptamer for one-pot and label-free detection of miRNA-133a

Talanta, Journal Year: 2025, Volume and Issue: 294, P. 128173 - 128173

Published: April 19, 2025

Language: Английский

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Nucleic Acid-mediated SERS Biosensors: Signal Enhancement Strategies and Applications

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: 282, P. 117519 - 117519

Published: April 25, 2025

Language: Английский

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CRISPR/Cas‐SERS Sensing Platforms: A Frontier Technology for Next‐Generation Fast, Low‐Cost, Ultra‐Micro Biosample Detection

Journal of Raman Spectroscopy, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

ABSTRACT Researchers have long been interested in nucleic acid detection technology. Surface‐enhanced Raman spectroscopy (SERS) is distinguished by its high sensitivity, minimal sample volume, resistance to fluorescence interference, cost‐effectiveness, and rapidity compared conventional analysis methods. The clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein (CRISPR/Cas), a novel gene editing tool, has garnered significant interest due precise identification isothermal advantages. Integrating the CRISPR/Cas system's specific capabilities with high‐sensitivity fingerprinting properties of SERS offers sensitive, ultra‐low rapid, straightforward method for detecting new modalities. This review delineates components characteristics system, encompassing three Cas proteins (Cas9, Cas12, Cas13) technologies derived from CRISPR/Cas, namely, enzymatic reporter unlocking (SHERLOCK) DNA endonuclease‐targeted CRISPR trans reporters (DETECTR). Advancements CRISPR/Cas‐SERS‐based assays were emphasized, traditional non‐nucleic tests. Examples encompass microfluidics/microdroplet‐based CRISPR/Cas‐SERS non‐amplified based on CRISPR/Cas‐SERS, so on.

Language: Английский

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A Novel Machine Learning-enhanced Microfluidic CircRNAs Detection Platform for Breast Cancer Precision Diagnosis

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

The discovery and favourable detection of breast cancer biomarkers are significant for diagnosis. Here, we show that hsa_circ_044235 hsa_circ_000250 effective Moreover, present an integrated electrochemical microfluidic circRNAs platform (ECMCDP) combined gold platinum nanoparticles (AuPts)-modified screen-printed electrodes (SPEs), catalytic hairpin assembly (CHA), chip a customed low-power electronic system simultaneous two cancer-associated circRNAs. limit (LOD) were 0.12 fM 0.1 fM, the diagnostic accuracy 92.50% 88.75% in clinical blood samples, respectively. was validated using paired pre-/post-operative tissue samples. Combined with five machine learning-based models, ensemble diagnosis model achieved high 93.75%. This work aims to identify novel establish innovative improve support prognosis assessment.

Language: Английский

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Rapid antigen test based on gold nanoparticles embedded with highly sensitive surface-enhanced Raman scattering probes for detecting antigen concentrations below the visual detection limit

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(6)

Published: May 8, 2025

Language: Английский

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Progress in biosensing applications of isothermal nucleic acid amplification techniques

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113919 - 113919

Published: May 1, 2025

Language: Английский

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DNA-mediated precise regulation of SERS hotspots for biosensing and bioimaging

Chemical Society Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review summarizes the recent advances in DNA-mediated precise regulation of SERS hotspots for biosensing and bioimaging.

Language: Английский

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