ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(44), P. 60070 - 60083
Published: Oct. 22, 2024
Multitarget
tyrosine
kinase
inhibitors
(TKIs)
serve
as
first-line
therapeutics
in
the
systemic
treatment
of
hepatocellular
carcinoma
(HCC),
yet
their
clinical
effectiveness
is
hampered
by
suboptimal
pharmacokinetics
and
bioavailability.
There
a
critical
need
to
enhance
circulation,
tumor
targeting,
infiltration
TKIs.
In
this
context,
we
developed
silk
fibroin
(SF)-based
nanomedicine
that
exploits
chemical
versatility
conformation
tunability
SF.
Folic
acid
(FA)
with
affinity
toward
HCC
cells
utilized
functionalize
SF,
simultaneously
aiding
pH-sensitive
β-sheet
transitions
This
dynamic
behavior
key
improving
nanomedicine's
biological
adhesion,
localization.
By
encapsulating
Lenvatinib
(Leva)
TKI,
exhibits
tumor-targeted
accumulation
potent
inhibition
on
cell
survival
angiogenesis,
thereby
amplifying
Leva's
bioavailability
therapeutic
impact.
Owing
SF's
low
immunogenicity
high
reproducibility,
SF-based
approach
for
TKI
delivery
holds
substantial
promise
advancing
therapy.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(29)
Published: May 12, 2024
The
activation
of
sequential
events
in
the
cancer-immunity
cycle
(CIC)
is
crucial
for
achieving
effective
antitumor
immunity.
However,
formidable
challenges,
such
as
innate
and
adaptive
immune
resistance,
along
with
off-target
adverse
effects
nonselective
immunomodulators,
persist.
In
this
study,
a
tumor-selective
nano-regulator
named
PNBJQ
has
been
presented,
focusing
on
targeting
two
nonredundant
nodes:
inducing
immunogenic
cancer
cell
death
abrogating
resistance
to
fully
activate
endogenous
tumor
obtained
by
encapsulating
immunomodulating
agent
JQ1
within
self-assembling
system
formed
linking
Type-I
photosensitizer
polyethylene
glycol
through
hypoxia-sensitive
azo
bond.
Benefiting
from
photosensitive
mechanism,
triggers
hypoxic
tumors
under
near-infrared
(NIR)
light
irradiation.
This
process
resolves
stimulating
sufficient
cytotoxic
T-lymphocytes.
Simultaneously,
smartly
responds
microenvironment
precise
drug
delivery,
adeptly
addressing
using
downregulate
programmed
ligand
1
(PD-L1)
sustaining
response
T
lymphocytes.
activatable
synergic
photoimmunotherapy
promotes
an
immune-promoting
activating
iterative
revolution
CIC,
which
remarkably
eradicates
established
suppresses
distal
lesions
low
dose
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(35), P. 23827 - 23841
Published: Aug. 20, 2024
Carrier-free
nanodrugs
with
extraordinary
active
pharmaceutical
ingredient
(API)
loading
(even
100%),
avoidable
carrier-induced
toxicity,
and
simple
synthetic
procedures
are
considered
as
one
of
the
most
promising
candidates
for
disease
theranostics.
Substantial
studies
commercial
success
"carrier-free"
nanocrystals
have
demonstrated
their
strong
clinical
potential.
However,
practical
translations
remain
challenging
impeded
by
unpredictable
assembly
processes,
insufficient
delivery
efficiency,
an
unclear
in
vivo
fate.
In
this
Perspective,
we
systematically
outline
contemporary
emerging
carrier-free
based
on
diverse
APIs,
well
highlight
opportunities
challenges
translation.
Looking
ahead,
further
improvements
design
preparation,
drug
delivery,
efficacy,
safety
nanomedicines
essential
to
facilitate
translation
from
bench
bedside.
ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Despite
its
therapeutic
potential,
photodynamic
therapy
faces
several
key
limitations
in
clinical
applications,
including
poor
drug
delivery
and
insufficient
tumor
selectivity.
We
engineered
RFYFYR-Ce6-RFYFYR
(R-Ce6-R),
a
twin-tail
peptide–photosensitizer
conjugate
that
self-assembles
into
nanostructures
for
improved
cancer
treatment.
By
incorporating
arginine-rich
peptide
sequences,
this
design
not
only
enhances
cellular
internalization
but
also
promotes
peroxynitrite
(ONOO–)
formation,
amplifying
the
effect.
Our
studies
revealed
R-Ce6-R
achieves
33-fold
higher
potency
than
unmodified
Ce6,
with
an
IC50
of
0.18
μM.
The
demonstrated
selective
accumulation
tissue,
robust
ROS
generation,
complete
regression
animal
models
while
maintaining
favorable
safety
profile.
These
results
establish
as
innovative
approach
advancing
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 7207 - 7218
Published: Oct. 24, 2024
Several
reports
are
available
on
aggregation-induced
emission
and
its
applications
in
biomedical
imaging
other
material
sciences.
However,
enhancement
of
singlet
oxygen
generation
nanoaggregates
is
rarely
reported.
Here,
we
report
the
synthesis
Naph-BODIPY
Br2,
which
absorbs
at
661
nm
(monomer)
with
a
high
molar
absorption
coefficient.
The
presence
bromine
promotes
intersystem
crossing,
thereby
enhancing
quantum
yield
(ΦΔ
∼
0.50
methanol).
In
order
to
increase
hydrophilicity,
developed
Br2
(∼100
nm),
demonstrated
properties
exhibited
bathochromic
shift
an
maximum
757
nm.
UV–vis
spectra
due
aggregation
corroborated
by
TD-DFT
analysis.
computational
data
also
confirm
low-lying
triplet
state,
enhances
oxygen,
making
it
effective
for
photodynamic
therapy.
These
aggregates
showed
excellent
aqueous
media,
compared
their
monomeric
form
standard
methylene
blue.
Their
hydrophilic
nature
enabled
significant
phototoxicity
against
human
carcinoma
cells
IC50
values
4.06
±
0.01
4.09
0.1
μM,
respectively,
MCF-7
A549
upon
5
min
exposure
light.
Moreover,
further
increases
increasing
time
light
both
cell
lines.
Notably,
nearly
zero
dark
toxicity
effectively
induced
apoptosis
cancer
activation,
highlighting
potential
as
powerful
photosensitizers
