ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(44), P. 60070 - 60083
Published: Oct. 22, 2024
Multitarget
tyrosine
kinase
inhibitors
(TKIs)
serve
as
first-line
therapeutics
in
the
systemic
treatment
of
hepatocellular
carcinoma
(HCC),
yet
their
clinical
effectiveness
is
hampered
by
suboptimal
pharmacokinetics
and
bioavailability.
There
a
critical
need
to
enhance
circulation,
tumor
targeting,
infiltration
TKIs.
In
this
context,
we
developed
silk
fibroin
(SF)-based
nanomedicine
that
exploits
chemical
versatility
conformation
tunability
SF.
Folic
acid
(FA)
with
affinity
toward
HCC
cells
utilized
functionalize
SF,
simultaneously
aiding
pH-sensitive
β-sheet
transitions
This
dynamic
behavior
key
improving
nanomedicine's
biological
adhesion,
localization.
By
encapsulating
Lenvatinib
(Leva)
TKI,
exhibits
tumor-targeted
accumulation
potent
inhibition
on
cell
survival
angiogenesis,
thereby
amplifying
Leva's
bioavailability
therapeutic
impact.
Owing
SF's
low
immunogenicity
high
reproducibility,
SF-based
approach
for
TKI
delivery
holds
substantial
promise
advancing
therapy.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
discusses
phototherapeutic
nanosystems
for
oral
cancer,
emphasizing
diverse
drug
delivery
systems,
advanced
photodynamic
therapy
approaches,
and
combination
therapies.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Abstract
Photodynamic
immunotherapy
which
combines
photodynamic
therapy
with
has
become
an
important
and
effective
method
for
the
treatment
of
cancer.
However,
most
cancer
immunotherapeutic
systems
are
not
able
to
achieve
precise
release
immunomodulators,
resulting
in
systemic
side
effects
poor
patient
outcomes.
Herein,
a
dual‐activatable
nano‐immunomodulator
(DIR
NP),
both
its
effect
agonist
can
be
activated
under
specific
stimuli,
is
reported
precision
immunotherapy.
The
DIR
NP
self‐assembled
from
R848‐conjugated
amphiphilic
polymer
(mPEG‐TK‐R848)
hydrophobic
oxidized
bovine
serum
albumin
(BSA‐SOH)‐conjugatable
photosensitizer
(DIR).
NPs
may
generate
small
amount
1
O
2
808
nm
laser
irradiation,
leading
cleavage
thioketal
(TK)
moiety
R848
DIR.
released
conjugate
tumor‐overexpressed
BSA‐SOH,
improving
efficiency
NIR‐II
fluorescence
signal.
Such
improvement
further
enhance
cargoes
upon
irradiation.
induces
immunogenic
cell
death
(ICD)
immune
factors
maturation
dendritic
cells
inhibiting
growth
primary
distant
tumors
eliminating
lung
metastasis.
Therefore,
this
study
provides
intelligent
regulation
tumor
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(44), P. 60070 - 60083
Published: Oct. 22, 2024
Multitarget
tyrosine
kinase
inhibitors
(TKIs)
serve
as
first-line
therapeutics
in
the
systemic
treatment
of
hepatocellular
carcinoma
(HCC),
yet
their
clinical
effectiveness
is
hampered
by
suboptimal
pharmacokinetics
and
bioavailability.
There
a
critical
need
to
enhance
circulation,
tumor
targeting,
infiltration
TKIs.
In
this
context,
we
developed
silk
fibroin
(SF)-based
nanomedicine
that
exploits
chemical
versatility
conformation
tunability
SF.
Folic
acid
(FA)
with
affinity
toward
HCC
cells
utilized
functionalize
SF,
simultaneously
aiding
pH-sensitive
β-sheet
transitions
This
dynamic
behavior
key
improving
nanomedicine's
biological
adhesion,
localization.
By
encapsulating
Lenvatinib
(Leva)
TKI,
exhibits
tumor-targeted
accumulation
potent
inhibition
on
cell
survival
angiogenesis,
thereby
amplifying
Leva's
bioavailability
therapeutic
impact.
Owing
SF's
low
immunogenicity
high
reproducibility,
SF-based
approach
for
TKI
delivery
holds
substantial
promise
advancing
therapy.
