Polydopamine Decorated Hyaluronic Acid Clusters for Tumor Cell Targeting Combination Therapy via Template Self‐Consumption Methods DOI
Hongrui Zhu,

Daqing Xia,

Huan He

et al.

Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Abstract Photothermal‐chemodynamic‐chemotherapy (PTT‐CDT‐CT) combination therapy significantly enhances the therapeutic efficacy against tumors. However, synthesizing PTT‐CDT‐CT nanosystems is complex, typically requiring preparation and conjugation of three components into a single carrier. To overcome this challenge, facile template self‐consumption method developed. In approach, hyaluronic acid (HA), recognized for its tumor cell targeting properties, chelates with Cu 2+ to form Cu‐HA, which then transforms CuO 2 @HA cluster templates. These templates self‐consume gradually, producing ·OH , catalyze rapid polymerization dopamine coordinate polydopamine respectively, enhancing photothermal conversion efficiency. After gossypol loading, GPDA@HA clusters are formed, achieving high loading efficiency due π–π stacking between PDA, as well coordination . The effectively internalized by cells through endocytosis, mediating synergistic damage or inhibition intracellular proteins, nucleic acids via PTT, CDT, CT. Crucially, synergism far surpasses those modality. This work introduces new pathway synthesis nanosystems, avoiding conventional different agents, provides insights developing personalized drug therapies efficacy.

Language: Английский

Thiophene engineering of near-infrared D-π-A nano-photosensitizers for enhanced multiple phototheranostics and inhibition of tumor metastasis DOI
Xingyu Zhao,

Jiaping Shen,

Huixuan Qi

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 291 - 303

Published: Jan. 17, 2025

Language: Английский

Citations

2
Engineering a Self-Delivery Nanoplatform for Chemo-Photodynamic-Immune Synergistic Therapies against Aggressive Melanoma DOI
Fei Wu,

Xianquan Feng,

Wenhao Gao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

The effectiveness of immunotherapy in killing melanoma is hindered by a T-cell deficiency and the lack tumor immunogenicity. Consequently, there an urgent need for platform that can further activate immune system boost response host to tumors. Compared with monotherapy, combination therapy shows promise improving treatment efficacy rates. This study introduces pioneering use rationally designed active targeting nanoplatform bind axitinib, paclitaxel, verteporfin human serum albumin (APV@HSA NPs). APV@HSA NPs have demonstrated capability induce dual-induced apoptosis cells through chemo- photodynamic effects, while also enhancing immunogenic cell death promoting dendritic maturation. Additionally, promoted production CD8+ T memory inhibited vascular endothelial growth factor via facilitating infiltration effector optimizing chemo-photodynamic immunotherapy. Hence, amplified chemo-photodynamic-immunological nanomedicines excellent biocompatibility been redesigned inhibit microenvironment combat primary lung metastasis. approach initiates series responses, presenting promising therapeutic strategy melanoma.

Language: Английский

Citations

0
A stimuli-responsive immunostimulant to activate chemo-immunotherapeutic effects by inducing DNA damage and STING activation DOI

Shuiying Zhang,

Hangyu Zhou, Yixin Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 664 - 676

Published: Feb. 26, 2025

Language: Английский

Citations

0
In situ construction of heterojunctions to regulate the biodegradation behavior of copper carriers for tumor-specific cuproptosis-enhanced sono-immunotherapy DOI Creative Commons
X. P. Cao,

Lingwei Mao,

Yijun Tian

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 25, 2025

Cuproptosis, a novel approach utilizing copper carriers to trigger programmed cell death, exhibits promise for enhancing traditional therapies and activating robust adaptive immune responses. However, the uncontrolled release of Cu ions risks triggering cuproptosis in healthy tissues, potentially causing irreversible damage. To address this, we report on use Cu-MOF (copper metal-organic framework) protective layer regulate biodegradation copper-based nanomaterials. In situ formation Cu2O nanocubes not only stabilizes material under physiological conditions but also enhances its sonodynamic therapy (SDT) capabilities by establishing Z-Scheme heterojunction. Upon SDT activation, targeted ion at tumor site triggers cascade reactions, generating reactive oxygen species (ROS) via Fenton-like processes depleting glutathione (GSH). This ROS surge, combined with effective cuproptosis, modulates immunosuppressive microenvironment, inducing immunogenic death eliminate primary tumors inhibit metastasis. study offers new paradigm controlled integration SDT, chemodynamic (CDT), immunotherapy, achieving precise tumor-targeted treatment nanomaterial degradation.

Language: Английский

Citations

0
A heterojunction-engineering nanodrug with tumor microenvironment responsiveness for tumor-specific cuproptosis and chemotherapy amplified sono-immunotherapy DOI
Yang Wang, Tingting Yan, Jinming Cai

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 321, P. 123319 - 123319

Published: April 4, 2025

Language: Английский

Citations

0
A copper missile-triggered power coalescence and death vortex within tumor cell mitochondria for synergistic cuproptosis/phototherapy/chemotherapy DOI
Yicheng Jiang, Shuhan He, Xiang Niu

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(34), P. 15967 - 15983

Published: Jan. 1, 2024

The CCTH nanoparticles trigger power coalescence and death vortex within tumor cell mitochondria, producing potent anti-tumor efficacy through cuproptosis/phototherapy/chemotherapy synergistic therapy.

Language: Английский

Citations

3
Metal‐organic frameworks‐based nanomedicines to promote cancer immunotherapy: Recent advances and future directions DOI Creative Commons
Chenqian Feng, Xiaoyan Liang, Rangrang Fan

et al.

MedComm – Biomaterials and Applications, Journal Year: 2024, Volume and Issue: 3(4)

Published: Oct. 19, 2024

Abstract Cancer immunotherapy uses the body's immune system to fight tumors by restoring natural antitumor responses. Metal‐organic frameworks (MOFs), characterized their unique crystalline porous structures formed from metal ions linked organic ligands, offer a promising solution. Recent studies have unveiled potential of MOFs in cancer immunotherapy. The exceptional porosity and surface area, coupled with extraordinary thermal chemical stability, bring significant advantages for efficient drug loading delivery immunotherapeutic agents. adaptability further enhances controlled release drugs within target cells increases tumor sensitivity other therapies such as photodynamic, photothermal, radiotherapy. This multifunctional carrier contributes modulating microenvironment reactivating immunity, providing comprehensive strategy treatment. In this review, we summarize applications checkpoint blockade, immunomodulator delivery, vaccine discuss existing challenges use discussion aims insights developing better treatments enhancing efficacy

Language: Английский

Citations

1
Nanoplatform-based synergistic cancer Immuno-Chemodynamic therapy DOI
Shuyi Kong, Jie Zhang, Baoyue Ding

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124956 - 124956

Published: Nov. 15, 2024

Language: Английский

Citations

1
Cuproptosis: an emerging domain for copper-based nanomaterials mediated cancer therapy DOI
Fan Zhao,

Zhuangzhuang Zhao,

Hao Gao

et al.

MedMat., Journal Year: 2024, Volume and Issue: 1(2), P. 74 - 94

Published: Dec. 1, 2024

Cuproptosis, a newly discovered copper-dependent mode of cell death, has received extensive attention in the field cancer therapy due to its specific activation pathway. Rapid accumulation large amounts copper ions within cells achieve overload is key activating cuproptosis. Advanced nanotechnology offers considerable promise for delivering cells, which copper-based nanomaterials have been proposed evoke cuproptosis-mediated therapy. However, it still great challenge induce specifically tumors and efficiently activate subsequent cuproptosis-related molecular pathways. Therefore, necessary summarize strategies used effectively or amplify cuproptosis based on currently developed nanomaterials, providing ideas design future. In this review, that can be are systematically classified selection. Subsequently, sensitization using provided therapeutic efficiency. Meanwhile, combination therapies maximizing treatment efficacy delineated. Ultimately, remaining challenges feasible future directions use tumor also discussed.

Language: Английский

Citations

1
Recent advances in chemotherapy for cancer therapy over Cu-based nanocatalysts DOI

Mengyu Wang,

Zhi‐Xin Li

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The recent progress of various Cu-based nanocatalysts in cancer therapy was reviewed, especially the remarkable achievements catalytic treatment tumor microenvironment through CDT and CDT-involved multimodal synergies.

Language: Английский

Citations

0