Tumor Microenvironment-Responsive MnOx-Mesoporous Carbon Nanoparticles for Enhanced Chemodynamic Synergistic Antitumor Therapy
ACS Applied Nano Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Developing
nanomedicines
with
simultaneous
diagnosis
and
treatment
functions
is
a
promising
therapeutic
strategy
for
cancer
therapy.
Herein,
multifunctional
manganese
oxide-mesoporous
carbon
nanoparticles
(MnOx-MCN
NPs)
were
designed
magnetic
resonance
imaging
(MRI)-guided
chemotherapy,
photothermal
therapy
(PTT),
chemodynamic
(CDT).
The
excellent
conversion
efficiency
(44.2%)
outstanding
fenton-like
catalytic
activity
endowed
MnOx-MCN
NPs
PTT/CDT
synergistic
Furthermore,
their
unique
mesoporous
structure,
can
also
act
as
drug
delivery
carrier
encapsulating
chemotherapy
agent
doxorubicin
(DOX).
mild
acid
tumor
microenvironment
(TME)
near-infrared
(NIR)
heat
induced
the
release
of
DOX.
In
addition,
NIR
laser
enhanced
CDT
NPs,
thus
generating
chemotherapy/PTT/CDT
effect.
Extracellular
experiments
demonstrated
that
generated
by
irradiation
could
encourage
generation
•OH.
More
importantly,
displayed
superior
anticancer
both
in
vitro
vivo.
Such
elaborately
synthesized
nanomaterial
provides
paradigm
design
other
multifunction
nanoagents.
Language: Английский
Nanogels—Innovative Drug Carriers for Overcoming Biological Membranes
Gels,
Journal Year:
2025,
Volume and Issue:
11(2), P. 124 - 124
Published: Feb. 8, 2025
Nanogels
are
promising
drug
delivery
systems
since
they
possess
undeniable
advantages
such
as
high
loading
capacity
for
hydrophilic
and
hydrophobic
drugs,
stabilization
of
sensitive
biocompatibility,
biodegradability.
The
present
review
summarizes
experimental
studies
related
to
carriers,
loading,
membrane
transport
nanogels.
In
particular,
the
discusses
properties,
advantages,
limitations
polymeric
carriers
with
respect
behavior
prepared
nanogels
in
vivo
conditions.
potential
nanogel
encapsulation
or
drugs
mechanisms
release
also
emphasized.
Moreover,
challenges
through
barriers
presented
parenteral,
oral,
ocular,
nasal,
dermal
routes
administration
considered.
Language: Английский
Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy
Xingchen Li,
No information about this author
Yuxuan Zhang,
No information about this author
Annan Liu
No information about this author
et al.
Journal of Colloid and Interface Science,
Journal Year:
2025,
Volume and Issue:
688, P. 44 - 58
Published: Feb. 19, 2025
Language: Английский
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
Shiyu Peng,
No information about this author
Xiaoxue Hou,
No information about this author
Jianfeng Liu
No information about this author
et al.
Journal of Controlled Release,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Recent advances and perspectives of multifunctional nanogels in biomedical applications
Buxing Han,
No information about this author
Zideng Dai,
No information about this author
Hangrong Chen
No information about this author
et al.
MedComm – Biomaterials and Applications,
Journal Year:
2024,
Volume and Issue:
3(4)
Published: Nov. 28, 2024
Abstract
Nanogels
(NGs)
are
considered
as
a
kind
of
nanoscale
hydrogels
(<200
nm)
endowing
with
the
functions
both
nanomaterials
and
hydrogels.
In
last
20
years,
NGs
have
garnered
significant
attention
due
to
their
versatility
adaptability.
Herein,
comprehensive
overview
latest
advancements
current
research
status
is
provided,
particular
focus
on
synthesis
strategies
involving
physical
chemical
cross‐linking
methods,
well
advantages
in
drug
loading
responsive
release.
Based
diverse
design
NGs,
four
key
biomedical
applications,
including
inflammation
therapy,
regenerative
medicine,
bioimaging
tumor
therapy
further
summarized
discussed.
Moreover,
existed
inherent
challenges
facing
proposed,
while
highlighting
potential
revolutionize
therapeutic
diagnostic
approaches.
Finally,
we
look
forward
development
promising
potentials
applications.
This
review
aims
serve
valuable
reference
for
researchers,
providing
some
insights
into
evolving
landscape
advanced
Language: Английский
Recent advances in chemotherapy for cancer therapy over Cu-based nanocatalysts
Mengyu Wang,
No information about this author
Zhi‐Xin Li
No information about this author
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
recent
progress
of
various
Cu-based
nanocatalysts
in
cancer
therapy
was
reviewed,
especially
the
remarkable
achievements
catalytic
treatment
tumor
microenvironment
through
CDT
and
CDT-involved
multimodal
synergies.
Language: Английский
Inhalable multi-stimulus sensitive curcumin-alginate nanogels for scavenging reactive oxygen species and anti-inflammatory co-ordination to alleviate acute lung injury
Jinyun Cai,
No information about this author
Haiyi Zhong,
No information about this author
Jianwei Luo
No information about this author
et al.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
unknown, P. 137816 - 137816
Published: Nov. 1, 2024
Language: Английский