Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect DOI
Yiyang Zhao,

Wanglin Duan,

Bin Zhu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Osteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate microenvironment of OA‐affected tissues. However, traditional fabrication methods DOPA‐based often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, different enzyme‐catalyzed activities platinum–copper (PtCu) at pH values are utilized directly catalyze cross‐linking DOPA‐modified hyaluronic acid (HAD), representing new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined PRP, mitigates generation proinflammatory factors, scavenges reactive oxygen species, boosts hypoxic chemotaxis chondrocytes, stimulates chondrocyte proliferation migration, protects interleukin‐1β‐treated human articular C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain improves knee osteoarthritic rats. These findings suggest provides alternative therapy.

Language: Английский

HPB@LA@PDA nanoplatform ameliorates osteoarthritis by scavenging reactive oxygen species and remodelling the inflammatory microenvironment: An in vitro and in vivo study DOI

Dongze Ren,

Mingjie Liu,

Min Cao

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160592 - 160592

Published: Feb. 1, 2025

Language: Английский

Citations

1
Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases DOI
Xiang Wang, Zidong Wang, Siyuan Hu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540

Published: Jan. 22, 2025

Language: Английский

Citations

0
Multiscale Metal-based Nanocomposites for Bone and Joint Disease Therapies DOI Creative Commons
Yuwen Wang,

Hasnain Jan,

Zhong Zheng

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101773 - 101773

Published: April 17, 2025

Bone and joint diseases are debilitating conditions that can result in significant functional impairment or even permanent disability. Multiscale metal-based nanocomposites, which integrate hierarchical structures ranging from the nanoscale to macroscale, have emerged as a promising solution this challenge. These materials combine unique properties of nanoparticles (MNPs), such enzyme-like activities, stimuli responsiveness, photothermal conversion, with advanced manufacturing techniques, 3D printing biohybrid systems. The integration MNPs within polymer ceramic matrices offers degree control over mechanical strength, antimicrobial efficacy, manner drug delivery, whilst concomitantly promoting processes osteogenesis chondrogenesis. This review highlights breakthroughs stimulus-responsive (e.g., photo-, magnetically-, pH-activated systems) for on-demand therapy their biocomposite hybrids containing cells extracellular vesicles mimic native tissue microenvironment. applications these composites extensive, bone defects, infections, tumors, degenerative diseases. emphasizes enhanced load-bearing capacity, bioactivity, be achieved through designs. Notwithstanding potential applications, barriers progress persist, including challenges related long-term biocompatibility, regulatory hurdles, scalable manufacturing. Finally, we propose future directions, machine learning-guided design patient-specific biomanufacturing accelerate clinical translation. bridge innovations macroscale functionality, revolutionary force field biomedical engineering, providing personalized regenerative solutions

Language: Английский

Citations

0
A novel metal‐organic framework encapsulated iridium oxide nanozyme enhanced antisense oligonucleotide combo for osteoarthritis synergistic therapy DOI Creative Commons
Shuqi Wu, Nan Fang, Kewen Zhang

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Abstract Osteoarthritis (OA) is associated with metabolic imbalance of articular cartilage and an increase intracellular reactive oxygen species (ROS). Synergistic therapy based on the codelivery ROS scavengers antisense oligonucleotides (ASO) into chondrocytes has potential to effectively treat OA. Here, we developed a novel biocompatible metal‐organic framework (MOF)‐encapsulated nanozyme/ASO delivery platform (miR/IrO 2 @ZIF‐8) for OA treatment. IrO nanoparticles catalytic activities superoxide dismutase/catalase were synthesized using hydrothermal method, resulting in excellent scavenging performance. was further loaded zeolitic imidazolate framework‐8 (ZIF‐8) maintain its efficacy regulate size, surface charge, biocompatibility enhance therapeutic effect platform. As effective ASO carrier, @ZIF‐8 exhibited high antagomiR‐181a loading lysosomal escape capacity, enabling it rebalance metabolism. In vitro experiments showed that miR/IrO could restore levels, mitochondrial membrane potential, lipid peroxidation chondrocytes. At same time, expression levels proinflammatory markers (IL‐1β, IL‐6, COX‐2) as well extracellular matrix degrading enzymes (ADAMTS‐5 MMP13) downregulated, indicating antioxidant, anti‐inflammatory, anticartilage degradation effects. Notably, able deliver tissue at depth up 1.5 mm, thus solving problems poor permeability difficult retention drugs tissue. This improves synergistic by inhibiting degradation. The combination MOF‐encapsulated nanozymes OA, offering promising translational medicine paradigm.

Language: Английский

Citations

2
Nanozyme‐Engineered Hyaluronic Acid Adhesives Loading Platelet‐Rich Plasma for Multilayered Osteoarthritis Treatment with Pain‐Relief Effect DOI
Yiyang Zhao,

Wanglin Duan,

Bin Zhu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Osteoarthritis (OA) is the most common degenerative joint disease, causing pain, disability, and economic strain. Combining nanozymes with dopamine (DOPA)‐based adhesives offers a promising approach to effectively modulate microenvironment of OA‐affected tissues. However, traditional fabrication methods DOPA‐based often involve external oxidants or curing agents, which can introduce additional oxidative stress, posing systemic risks. Here, different enzyme‐catalyzed activities platinum–copper (PtCu) at pH values are utilized directly catalyze cross‐linking DOPA‐modified hyaluronic acid (HAD), representing new polymerization method for phenol‐based bioadhesives. The resulting adhesive (HAD/PtCu/platelet‐rich plasma (PRP)), when combined PRP, mitigates generation proinflammatory factors, scavenges reactive oxygen species, boosts hypoxic chemotaxis chondrocytes, stimulates chondrocyte proliferation migration, protects interleukin‐1β‐treated human articular C28/I2 cells from further OA advancement. Additionally, in vivo assessments show that HAD/PtCu/PRP significantly alleviates pain improves knee osteoarthritic rats. These findings suggest provides alternative therapy.

Language: Английский

Citations

0