The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases DOI Open Access

Jing Ma,

Xue Li, Chunru Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13158 - 13158

Published: Dec. 7, 2024

Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people's lives health. To date, therapeutics with high therapeutic efficacy low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatment. Here, we first introduce diversity their different physicochemical properties on function. Following this, analyze potential enhance targeting by overcoming challenges traditional delivery methods through surface modifications, structural adjustments, optimized drug loading. Then, application structurally pancreatic-related diseases. For instance, cancer (as platforms, for promotion radiation therapy, as multifunctional tools), pancreatitis systems, anti-inflammatory anti-fibrotic agents), diabetes insulin carriers, protecting β cells, improving resistance). Through analysis progress current research, summarize how can treatment while minimizing effects. Finally, look forward prospects

Language: Английский

The role of the natural compound naringenin in AMPK-mitochondria modulation and colorectal cancer inhibition DOI Creative Commons
Dan Wang, Yue Zhou,

Li Hua

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 131, P. 155786 - 155786

Published: May 28, 2024

Although AMP-activated protein kinase (AMPK) has been extensively studied in cellular processes, the understanding of its substrates, downstream functions, contributions to cell fate and colorectal cancer (CRC) progression remains incomplete.

Language: Английский

Citations

8
Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects DOI Creative Commons
J. B. Thomas, Vinay Kumar, Neha Sharma

et al.

Medicine in Drug Discovery, Journal Year: 2025, Volume and Issue: unknown, P. 100204 - 100204

Published: Feb. 1, 2025

Language: Английский

Citations

1
Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery DOI
Yuhong Ma, Bing Zhao,

Umm E. Hani

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161732 - 161732

Published: March 1, 2025

Language: Английский

Citations

0
Nano-Phytoconstituents: Recent Advances, Regulatory Insights, Challenges, and Future Horizons DOI
M H Miran Beygi, Fatemeh Oroojalian, Sercan Karav

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106908 - 106908

Published: April 1, 2025

Language: Английский

Citations

0
Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery DOI
Yuhong Ma, Jingru Yang,

Yukun Ma

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Despite the potential benefits of close‐looped insulin delivery systems in regulating glycemic homeostasis and effectively alleviating diabetes, they still encounter challenges such as limited effectiveness preventing low episodes due to sluggish glucose response, issues with instability enzymes carriers. In this study, dually‐crosslinked oxidase (GOx)‐immobilized nanogels (DC‐NGs@Ins) are developed for rapid‐responsive sustained hypoglycemic therapy. The DC‐NGs@Ins phenylborate ester linker enabled release a fashion, moreover, immobilized GOx‐generated hydrogen peroxide (H 2 O ) by consuming glucose, which can further bind enhancing response accelerating release. structure (phenylboronic UV‐crosslinking) minimized initial burst insulin, thus risk hypoglycemia. More interestingly, GOx mitigated leakage enhanced its multiple utilization compared free GOx. vivo study demonstrated that maintained levels (BGLs) below 200 mg dL −1 at least 8 h singly‐crosslinked (SC‐NGs@Ins). Therefore, intelligent system shows applications diabetes treatment.

Language: Английский

Citations

1
Propionate-functionalized chitosan hydrogel nanoparticles for effective oral delivery of insulin DOI
Yaqiong Chen, Hongdong Song, Xinyue Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139159 - 139159

Published: Dec. 1, 2024

Language: Английский

Citations

1
Effects of silica nanoparticle addition and PDMS coating on membrane performance and stability in the extraction of aromatic amines DOI
Gilles Van Eygen, Arnaud Gilles, Julieta García-Chirino

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 683, P. 68 - 78

Published: Dec. 9, 2024

Language: Английский

Citations

0
The Application of Nanomaterials in the Treatment of Pancreatic-Related Diseases DOI Open Access

Jing Ma,

Xue Li, Chunru Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13158 - 13158

Published: Dec. 7, 2024

Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people's lives health. To date, therapeutics with high therapeutic efficacy low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatment. Here, we first introduce diversity their different physicochemical properties on function. Following this, analyze potential enhance targeting by overcoming challenges traditional delivery methods through surface modifications, structural adjustments, optimized drug loading. Then, application structurally pancreatic-related diseases. For instance, cancer (as platforms, for promotion radiation therapy, as multifunctional tools), pancreatitis systems, anti-inflammatory anti-fibrotic agents), diabetes insulin carriers, protecting β cells, improving resistance). Through analysis progress current research, summarize how can treatment while minimizing effects. Finally, look forward prospects

Language: Английский

Citations

0