Mitochondria Localized Anticancer Iridium(III) Prodrugs for Targeted Delivery of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors and Cytotoxic Iridium(III) Complex

Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Myeloid cell leukemia-1 (Mcl-1) is an antiapoptotic oncoprotein overexpressed in several malignancies and acts as one of the promising therapeutic targets for cancer. Even though there are small molecule based Mcl-1 inhibitors reported, delivery inhibitor at target site quite challenging. In this regard, we developed a series mitochondria targeting luminescent cyclometalated iridium(III) prodrugs bearing via ester linkage due to presence protein outer mitochondrial membrane. Among synthesized prodrugs, IrThpy@L2 was found exhibit potent cytotoxicity (IC

Language: Английский

Research Progress of Endoplasmic Reticulum Targeting Metal Complexes in Cancer Therapy

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(8)

Published: Dec. 1, 2024

ABSTRACT The development of anticancer drugs that target different organelles has received extensive attention due to the characteristics cancer recurrence, metastasis, and drug resistance. endoplasmic reticulum (ER) is an important structure within cell primarily responsible for protein synthesis, folding, modification, transport plays a crucial role in function health. ER stress activation induces apoptosis. New with mechanisms selectivity can be designed because redox activity, composition diversity, metal complexes regulation. Over past few decades, dozens have killed cells through stress, showing powerful tumor‐suppressive effects. This review summarizes progress research on metallic induce over years, which expected bring more breakthroughs field medicine life science.

Language: Английский