Recent Development of Nanozymes for Combating Bacterial Drug Resistance: A Review

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

The World Health Organization has warned that without effective action, deaths from drug-resistant bacteria can exceed 10 million annually, making it the leading cause of death. Conventional antibiotics are becoming less due to rapid bacterial drug resistance and slowed new antibiotic development, necessitating strategies. Recently, materials with catalytic/enzymatic properties, known as nanozymes, have been developed, inspired by natural enzymes essential for eradication. Unlike recent literature reviews broadly cover nanozyme design biomedical applications, this review focuses on latest advancements in nanozymes combating resistance, emphasizing their design, structural characteristics, applications combination therapy, future prospects. This approach aims promote development especially towards clinical translation.

Language: Английский

---

Rapidly self-crosslinking sodium alginate hydrogel for infected wounds

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Jan. 6, 2025

The risks associated with wound infections are significant, making a snug-fitting hydrogel dressing an optimal choice for management. For it, we employed the self-cross-linking method of oxidized sodium alginate (SCSA), incorporating clarithromycin (Cla) and basic fibroblast growth factor (bFGF) to formulate rapidly forming, bacteriostatic, wound-healing (SCSA@C/b). Bacteriostatic cytocompatibility assays demonstrated that SCSA@C/b exhibits exceptional antibacterial activity alongside strong biocompatibility. A fractional infected model showed accelerated healing wounds by approximately three days compared time control group, nearly complete recovery. H&E staining SEM analysis healed sections revealed significant pro-healing effects. Thus, is promising medicinal encouraging in contaminated areas.

Language: Английский

---

The Pd nanoparticles-modified porphyrin metal-organic framework as highly efficient oxidase mimics for colorimetric quantification and discrimination of oleuropein

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136236 - 136236

Published: Jan. 1, 2025

Language: Английский

---

Nanoconfinement-guided in situ co-deposition of single-atom cascade nanozymes combined with injectable sodium alginate hydrogels for enhanced diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140814 - 140814

Published: Feb. 1, 2025

Language: Английский

---

Efficiently selective inactivation of Gram-positive bacteria by MCM-41 molecular sieve-supported copper-based self-cascading nanozymes

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160948 - 160948

Published: Feb. 1, 2025

Language: Английский

---

Peptide-photosensitizer conjugates: From molecular design to function and antibacterial applications

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162723 - 162723

Published: April 1, 2025

Language: Английский

---

AuCu@CuO₂ Aerogels with H₂O₂/O₂ Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Diabetic wound healing presents serious clinical challenges due to the unique microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO 2 )‐coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme‐mimicking activity H O /O self‐supplying modulate complex of methicillin‐resistant staphylococcus aureus (MRSA) ‐infected diabetic wounds. The AuCu@CuO aerogels demonstrate favorable photothermal properties mimic four enzyme‐like activities: peroxidase‐like for producing toxic reactive oxygen species; catalase‐like decomposing release relieve stress hypoxia; glucose oxidase‐like reducing blood glutathione balancing abnormal level. CuO coating facilitates continuous adequate in situ production within mildly acidic infection microenvironment, enabling excellent antibacterial reduced levels during initial treatment infected Furthermore, engineered not only scavenge elevated ROS inflammatory phase but also synergistically generate promote healing. Overall, aerogelsmicroenvironment can be activated microenvironments, alleviating inflammation, hypoxia, lowering levels, enhancing angiogenesis collagen fiber accumulation, thereby significantly improving

Language: Английский

---

Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156850 - 156850

Published: Oct. 1, 2024

Language: Английский

---

Construction of multifunctional hydrogel containing pH-responsive gold nanozyme for bacteria-infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137746 - 137746

Published: Nov. 1, 2024

Language: Английский

---

Spatially confined Co nanoparticles in N doped carbon material for high efficiency capacitive deionization

Desalination, Journal Year: 2024, Volume and Issue: 600, P. 118479 - 118479

Published: Dec. 27, 2024

Language: Английский

---