Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(32)

Published: Oct. 14, 2024

Abstract Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics the main clinical treatment method chronic wound infections. However, overuse of may accelerate emergence drug‐resistant bacteria, poses a significant threat to human health. Therefore, there is urgent need develop new therapeutic strategies Nanozyme‐based antimicrobial therapy (NABT) emerging strategy with broad‐spectrum activity and low drug resistance compared traditional antibiotics. NABT has shown great potential as catalyzing generation reactive oxygen species (ROS) its enzyme‐like catalytic properties, producing powerful bactericidal effect without developing resistance. cascade technology offers approach infection control, effectively improving efficacy activating cascades against cell membranes intracellular DNA while minimizing side effects. it worth noting that this still in early stages research. This article comprehensively reviews classification, current methods infection, different types nanozymes, application nanozyme reaction therapy, future challenges prospects.

Language: Английский

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Efficient bionic nanozyme based on AuPt NPs@ZIF-90 used for cyclic catalysis multimodal tumor therapy

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(48), P. 12597 - 12607

Published: Jan. 1, 2024

Multimodal therapy based on nanozyme is expected to become a novel option for tumor treatment. However, the catalytic efficiency of nanozymes and hypoxia microenvironment tumors limit therapeutic effect nanozymes. Herein, we screened small molecule midazole-2-carboxaldehyde (ICA) prepare ZIF-90 embedded gold platinum nanoparticles obtain ZAAP. ZAAP possessed multi-enzymatic cascade processes including greatly enhanced peroxidase activity

Language: Английский

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A pH-responsive copper selenide nanozyme modulates multiple enzyme activities for improved healing of infected wounds

Applied Materials Today, Journal Year: 2024, Volume and Issue: 41, P. 102518 - 102518

Published: Nov. 20, 2024

Language: Английский

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Biomimetic FeNi-MOF assisted intelligent theranostic hydrogels for pH identification and treatment of wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154945 - 154945

Published: Aug. 23, 2024

Language: Английский

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