Integration of Fe(III)-Chelated Polydopamine and Diallyl Trisulfide for Boosting Ferroptosis to Reverse Multidrug Resistance and Inducing Synergistic Tumor Nanotherapy DOI

Yiwang Zhao,

Shunyu Yao, Jing Huang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25580 - 25592

Published: Nov. 2, 2024

Multidrug resistance (MDR) has long been a fundamental obstacle in tumor chemotherapy. MDR is often associated with overexpression of an adenosine triphosphate (ATP)-binding cassette transporter resistant cancer cells, which highly ATP-dependent. Therefore, reversing by down-regulated ATP expression promising strategy. This study developed redox-regulating nanotherapeutic for boosting ferroptosis, MDR, and inducing synergistic therapy. Fe(III)-chelated polydopamine (Fe-PDA) the key to design such nanotherapeutic, laser irradiation can speed up electron transfer between Fe3+ Fe2+ production hydroxyl radical (•OH). Coating layer Fe-PDA on surface mesoporous silica (MSN)-encapsulated diallyl trisulfide (DATS), doxorubicin (DOX) was loaded Fe-PDA. Upon triggering, (DATS@MSN@Fe-PDA/DOX, DMFPD) produced photothermal (•OH) hydrogen sulfide (H2S) apoptotic cell death. The DATS depleted intracellular glutathione (GSH), together H2S boosted ferroptosis. Ferroptosis effectively caused mitochondrial dysfunction, thereby suppressing expression. interactive death chemotherapy sensitization were further demonstrated 4T1 tumor-bearing mouse model high level biosafety. provides strategy clinical theragnostics.

Language: Английский

Emerging COX-2 inhibitors-based nanotherapeutics for cancer diagnosis and treatment DOI

Ruiping Huang,

Yu Jiang, Baoyue Zhang

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122954 - 122954

Published: Nov. 7, 2024

Language: Английский

Citations

5
Self-Healing Photothermal Nanotherapeutics for Enhanced Tumor Therapy through Triple Ferroptosis Amplification and Cascade Inflammation Inhibition DOI
Yilin Zheng, Fangying Zheng,

Ruofei Xu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

The therapeutic effectiveness of photothermal therapy (PTT) is limited by heat tolerance and PTT-induced inflammation, which increases the risk tumor metastasis recurrence. Ferroptosis combined with PTT can achieve significant effects. In this work, we designed self-healing nanotherapeutics to effective triple-amplified ferroptosis cascade inflammation inhibition after treatment. After ferroptosis-inducing ability mangiferin (MF) was first elucidated, nanocomplex PFeM, coordinated Fe

Language: Английский

Citations

4
Application of metal polyphenol nanonetworks in phototherapy DOI
Siwei Li, Meng Cui,

Chunxiu Cai

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 539, P. 216743 - 216743

Published: April 23, 2025

Language: Английский

Citations

0
Ferroptosis by nanomaterials: targeting cancer stem cells and overcoming drug resistance DOI Creative Commons
Xiaoman Wang,

Jing Luo,

Xuemei Zeng

et al.

Acta Materia Medica, Journal Year: 2025, Volume and Issue: 4(3)

Published: Jan. 1, 2025

Tumor ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, has emerged as promising therapeutic strategy for combating cancers, particularly in cases involving cancer stem cells (CSCs) and drug resistance. In recent years nanomaterial-based approaches have gained significant attention the potential to selectively induce ferroptosis while sparing normal tissues. This review aims provide comprehensive overview current state-of-the-art utilizing nanomaterials targeting tumor with specific focus on application eradicating CSCs overcoming resistance mechanisms. The molecular mechanisms underlying induction nanomaterials, unique properties functionalities various nanomaterial platforms, strategies using nanoferroptosis will be discussed. addition, preclinical clinical evidence supporting efficacy platforms evaluated. Furthermore, challenges future perspectives development translation nanoferroptosis-based therapies precision treatment highlighted.

Language: Английский

Citations

0
Four birds with one Stone: A Lactose-Targeted supramolecular nanoprodrug for combined Photodynamic/Photothermal/NO/ chemotherapy of multidrug resistant cancer DOI
Chang Du, Jianbo Zhang,

Yingnan Zhou

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163787 - 163787

Published: May 1, 2025

Language: Английский

Citations

0
Integration of Fe(III)-Chelated Polydopamine and Diallyl Trisulfide for Boosting Ferroptosis to Reverse Multidrug Resistance and Inducing Synergistic Tumor Nanotherapy DOI

Yiwang Zhao,

Shunyu Yao, Jing Huang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 25580 - 25592

Published: Nov. 2, 2024

Multidrug resistance (MDR) has long been a fundamental obstacle in tumor chemotherapy. MDR is often associated with overexpression of an adenosine triphosphate (ATP)-binding cassette transporter resistant cancer cells, which highly ATP-dependent. Therefore, reversing by down-regulated ATP expression promising strategy. This study developed redox-regulating nanotherapeutic for boosting ferroptosis, MDR, and inducing synergistic therapy. Fe(III)-chelated polydopamine (Fe-PDA) the key to design such nanotherapeutic, laser irradiation can speed up electron transfer between Fe3+ Fe2+ production hydroxyl radical (•OH). Coating layer Fe-PDA on surface mesoporous silica (MSN)-encapsulated diallyl trisulfide (DATS), doxorubicin (DOX) was loaded Fe-PDA. Upon triggering, (DATS@MSN@Fe-PDA/DOX, DMFPD) produced photothermal (•OH) hydrogen sulfide (H2S) apoptotic cell death. The DATS depleted intracellular glutathione (GSH), together H2S boosted ferroptosis. Ferroptosis effectively caused mitochondrial dysfunction, thereby suppressing expression. interactive death chemotherapy sensitization were further demonstrated 4T1 tumor-bearing mouse model high level biosafety. provides strategy clinical theragnostics.

Language: Английский

Citations

1