Microneedle drug delivery carriers capable of achieving sustained and controlled release function DOI

Guangxi Zhai,

Jiayi Shao,

Yunshu Xu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114767 - 114767

Published: May 6, 2025

Language: Английский

Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective DOI

Devesh Kumar,

Shubham Pandey,

Jailani Shiekmydeen

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 8, 2025

Language: Английский

Citations

8
Multifunctional microneedle patch synergized with electrical stimulation to regulate microenvironment for enhanced healing of infected diabetic wounds DOI
Weikun Li, Xin Tan,

Yanling Liang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159255 - 159255

Published: Jan. 5, 2025

Language: Английский

Citations

3
Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections DOI

Quanyi Lu,

Xiangsheng Tang,

Bailong Tao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 296, P. 139685 - 139685

Published: Jan. 10, 2025

Language: Английский

Citations

3
Development of an aminoguanidine hybrid hydrogel composites with hydrogen and oxygen supplying performance to boost infected diabetic wound healing DOI
Yilei Yang, Dejun Ding, Changbao Huang

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137401 - 137401

Published: March 1, 2025

Language: Английский

Citations

0
A Visible-Light Photocatalysis/Hydrolysis Hydrogen-Generating Nanoplatform for Dynamic Inflammation Management via Immune Metabolism Orchestration during Wound Repair DOI

Zhaoyu Xu,

Yang Yang,

Xinhui Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Effective management of inflammation is one the promising strategies to prevent formation chronic wounds. Despite hydrogen being a prospective molecule for anti-inflammatory effects, on-demand delivery that could synchronize with dynamic stages has yet remained unaddressed. Moreover, its specific immunomodulatory mechanisms are still veiled. In this study, we introduced ISO-ZIF-8@AB, hydrogen-generating nanoplatform integrated visible-light photocatalysis and hydrolysis reactions achieve controllable release on demand, functioning an initial peak following sustained release. With ISO-ZIF-8@AB further loaded into aligned ECM-like scaffold, complex significantly alleviated prevented protracted unhealing. The bulk-RNA sequencing combined single-cell RNA revealed treatment effectively reduced excessive aggregation infiltration innate immune cells. Specifically, proportion Ptgs2+Nos2+ pro-inflammatory macrophages (PIMs) by mitigating mitochondrial stress suppressing HIF-1α-induced glycolysis, immune-metabolic regulation which harmful crosstalk between PIMs hypodermal fibroblasts facilitated extracellular matrix production accompanied ultimate wound repair. Overall, study presented strategy in terms timing rate, discussions regarding underlying therapy.

Language: Английский

Citations

0
Anti-inflammatory PEGylated bilirubin microneedle patch for diabetes treatment DOI

Yichen Kuang,

Fengfeng Xue,

Zideng Dai

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 39, P. 102295 - 102295

Published: June 15, 2024

Language: Английский

Citations

3
Nanoconfinement of Ammonia Borane via Hybrid‐Phased Titanate Nanocrystals Enables Sustained H2 Release for Diabetic Bone Repair DOI
Yuan Zhang, Fuwei Liu, Minggang Yang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Abstract Despite its potential in hydrogen (H 2 ) therapy, ammonia borane (AB) has limited biomedical applications due to uncontrolled hydrolysis rate and cause cytotoxicity. Existing material‐based delivery strategies focus on accelerating AB for H production, hence exacerbating these issues. A new nanoconfinement strategy is reported, which loads onto oxygen‐deficient, hybrid‐phased titanate nanocrystals implant surfaces through a unique one‐end‐anchored docking (OEAD) mechanism. This effectively restricts the release of molecules, allowing only water molecules infiltrate interlayer space slow sustained release. significantly prolongs duration circumvents cytotoxicity associated with interacting peroxide O inflammatory microenvironment. In vitro vivo have shown that from surface alleviates diabetes‐related oxidative stress, combined magnesium ions (Mg 2+ synergistically promotes innervated‐vascularized bone regeneration.

Language: Английский

Citations

0
Microneedle drug delivery carriers capable of achieving sustained and controlled release function DOI

Guangxi Zhai,

Jiayi Shao,

Yunshu Xu

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 253, P. 114767 - 114767

Published: May 6, 2025

Language: Английский

Citations

0