Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen DOI Creative Commons
Youfa Wang, Jie Han, Geoffrey I. N. Waterhouse

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

ABSTRACT The accurate and sensitive detection of low‐abundance cancer‐related biomarkers in blood remains a key technical challenge clinical applications. Herein, simple sandwich‐type electrochemical immunosensor based on stable hydrogen‐bonded cobalt‐porphyrin framework (Co‐HOF) was successfully developed for the ultrasensitive biomarker, carcinoembryonic antigen (CEA). antibody‐modified Co‐HOF forms sandwich structure with CEA aptamer electrode exclusively presence CEA, enabling specific CEA. signal increased linearly concentration demonstrating wide linear range (0.001–50 ng mL −1 ) low limit (0.22 pg ), surpassing performance commercial ELISA kits most reported methods. sensor employed spiked human serum, recoveries ranging from 85.04% to 105.20%. Additionally, we collected samples colorectal cancer patients healthy individuals clinically validate sensor, observing that levels progression. results showed strong consistency ( R 2 = 0.995) those obtained kits, proposed sensor's practicality related biomarkers.

Language: Английский

Construction of a purine bases electrochemical sensing platform based on NH2-MXene@COFTA-DH/GCE for simultaneous detection of guanine and adenine DOI
Ruixue Yan, Hao Guo,

Zeyun Yang

et al.

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136572 - 136572

Published: March 1, 2025

Language: Английский

Citations

0
Establishment of the rapid electrochemical-SELEX monitoring system by using ACEF technique and its application to dengue virus aptasensor fabrication DOI
Moonbong Jang,

Hanbin Park,

Hyunjun Park

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154806 - 154806

Published: Aug. 12, 2024

Language: Английский

Citations

3
Construction of Pyrrolo[3,2-b]pyrrolyl-linked Covalent Organic Polymers to Promote Continuous Overall H2O2 Production DOI
Yingguo Li,

Jialun He,

Chensheng Wang

et al.

Nano Energy, Journal Year: 2024, Volume and Issue: unknown, P. 110397 - 110397

Published: Oct. 1, 2024

Language: Английский

Citations

2
Construction of Pyrrolo[3,2-B]Pyrrolyl-Linked Covalent Organic Polymers to Promote Continuous Overall H2o2 Production DOI
Yingguo Li,

Jialun He,

Chensheng Wang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
A dual-switch electrochemical aptasensor for label-free detection of thrombin and ATP based on split aptamers DOI
Mingyang Song, Xiaowei Wu,

Kaiyan Fan

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1335, P. 343441 - 343441

Published: Nov. 19, 2024

Language: Английский

Citations

0
Stable Hydrogen‐Bonded Cobalt‐porphyrin Framework for High‐Performance Electrochemical Detection of Carcinoembryonic Antigen DOI Creative Commons
Youfa Wang, Jie Han, Geoffrey I. N. Waterhouse

et al.

Aggregate, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

ABSTRACT The accurate and sensitive detection of low‐abundance cancer‐related biomarkers in blood remains a key technical challenge clinical applications. Herein, simple sandwich‐type electrochemical immunosensor based on stable hydrogen‐bonded cobalt‐porphyrin framework (Co‐HOF) was successfully developed for the ultrasensitive biomarker, carcinoembryonic antigen (CEA). antibody‐modified Co‐HOF forms sandwich structure with CEA aptamer electrode exclusively presence CEA, enabling specific CEA. signal increased linearly concentration demonstrating wide linear range (0.001–50 ng mL −1 ) low limit (0.22 pg ), surpassing performance commercial ELISA kits most reported methods. sensor employed spiked human serum, recoveries ranging from 85.04% to 105.20%. Additionally, we collected samples colorectal cancer patients healthy individuals clinically validate sensor, observing that levels progression. results showed strong consistency ( R 2 = 0.995) those obtained kits, proposed sensor's practicality related biomarkers.

Language: Английский

Citations

0