Electrospinning: A New Frontier in Peptide Therapeutics
AAPS PharmSciTech,
Journal Year:
2025,
Volume and Issue:
26(3)
Published: Feb. 26, 2025
Language: Английский
Electrospun Nanofiber Platforms for Photodynamic Therapy: Role and Efficacy in Cancer, Antimicrobial, and Wound Healing Applications
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Electrospinning
offers
a
versatile
platform
for
developing
nanofibrous
scaffolds
capable
of
enhancing
the
therapeutic
potential
photodynamic
therapy
(PDT).
Photosensitizer
(PS)
loaded
fibers
exhibit
high
surface
area‐to‐volume
ratio,
promoting
efficient
drug
delivery,
prolonged
retention
at
target
site,
and
controlled
release
profiles.
Inducing
reactive
oxygen
species
(ROS)
generation
through
light
activation
targeted
approach,
selectively
generating
cytotoxic
effects
in
cancerous
or
pathogenic
cells
while
minimizing
damage
to
healthy
tissue.
This
selective
cytotoxicity
arises
because
ROS
are
produced
only
illuminated
areas
where
PS
releases
accumulates,
limiting
their
harmful
desired
regions.
Additionally,
PS‐loaded
highly
effective
wound
healing
applications,
cell
proliferation
tissue
regeneration
providing
barrier
against
microbial
infections.
review
highlights
recent
advances
design
biomedical
application
nanofibers,
emphasizing
influence
on
viability
effectiveness
inhibition,
thereby
setting
stage
future
innovations
cancer
therapy,
healing,
infection
control.
Language: Английский
Nanofiber Drug Delivery Systems: Recent Advances in Nanofabrication and Their Role in Targeted Therapy in Cancer, Neurodegenerative, and Cardiovascular Diseases
Satyam Yadav,
No information about this author
Amit Sharma,
No information about this author
Balak Das Kurmi
No information about this author
et al.
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(5)
Published: May 1, 2025
ABSTRACT
Nanofiber‐based
drug
delivery
systems
show
strong
potential
due
to
their
high
surface
area‐to‐volume
ratio
and
adjustable
structure.
Recent
studies
demonstrated
loading
efficiencies
exceeding
85%,
with
sustained
release
kinetics
up
96
h.
In
cancer
models,
nanofiber‐based
carriers
improved
accumulation
at
tumor
sites
by
3–4
fold
compared
conventional
formulations,
enhancing
therapeutic
efficacy
minimizing
systemic
toxicity.
This
review
outlines
methods
for
precise
nanofiber
shape
function
control
through
electrospinning
solution
blow
spinning
techniques.
advancements
in
technology
have
proven
promising
biomedical
applications
where
they
are
utilized
tissue
engineering,
neurodegenerative
disease
management,
wound
healing,
targeted
therapy.
Nanofibers
as
an
optimal
system
that
improves
cellular
restoration,
together
controlled
deep
penetration
capabilities.
The
recent
development
of
dual‐drug
systems,
stimuli‐responsive
nanofibers,
scaffolds
composed
nanofibers
smart
materials
has
expanded
usage
precision
medicine.
Research
now
demonstrates
facilitate
remodeling
functions
along
angiogenesis
promotion,
inflammatory
response
stability
improvement.
also
focuses
on
the
patents
a
system.
addition,
this
presents
new
approaches
overcome
these
challenges
based
interdisciplinary
cooperation,
AI‐driven
design
such
sophisticated
bioinformatics
tools.
review,
advances
prospects
realizing
revolution
field
improving
healthcare
outcomes
presented
detailed
overview.
Language: Английский
Redox/NIR dual-responsive glutathione extended polyurethane urea electrospun membranes for synergistic Chemo-Photothermal therapy
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
669, P. 125108 - 125108
Published: Dec. 20, 2024
Language: Английский
Chitosan/Hyaluronate Complex-Coated Electrospun Poly(3-hydroxybutyrate) Materials Containing Extracts from Melissa officinalis and/or Hypericum perforatum with Various Biological Activities: Antioxidant, Antibacterial and In Vitro Anticancer Effects
Polymers,
Journal Year:
2024,
Volume and Issue:
16(15), P. 2105 - 2105
Published: July 24, 2024
The
present
study
aimed
to
fabricate
innovative
fibrous
materials
with
various
biological
activities
from
poly(3-hydroxybutyrate),
sodium
hyaluronate
(HA),
chitosan
(Ch),
Language: Английский
Core–Sheath Fibers via Single-Nozzle Spinneret Electrospinning of Emulsions and Homogeneous Blend Solutions
Materials,
Journal Year:
2024,
Volume and Issue:
17(21), P. 5379 - 5379
Published: Nov. 4, 2024
The
preparation
of
core–sheath
fibers
by
electrospinning
is
a
topic
significant
interest
for
producing
composite
with
distinct
core
and
sheath
functionalities.
Moreover,
in
fibers,
low-molecular-weight
substances
or
nanosized
inorganic
additives
can
be
deposited
targeted
manner
within
the
sheath.
Commonly,
obtaining
structure,
coaxial
used.
It
requires
spinneret
suitable
immiscible
solvents
inner
outer
solutions.
single-nozzle
emulsions
address
these
issues,
but
use
stabilizing
agent
needed.
A
third
approach—preparation
homogeneous
blend
solutions
two
polymers
polymer/low-molecular-weight
substance—has
been
much
less
studied.
circumvents
difficulties
associated
emulsion
thoroughly
discussed
this
review.
formation
case
attributed
to
phase-separation-driven
self-organization
during
process.
Some
possibilities
core–double
using
same
method
are
also
indicated.
gained
knowledge
on
potential
applications
prepared
discussed.
Language: Английский