Drug Delivery Systems Based on Metal–Organic Frameworks for Tumor Immunotherapy

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 225 - 225

Published: Feb. 10, 2025

Metal–organic frameworks (MOFs) are a class of inorganic-organic hybrid nanoparticles formed by the coordination metal ions/clusters and organic ligands. Due to their high porosities, large surface areas, adjustable structures, responsiveness light/sound, etc., MOFs have shown great clinical potential in field tumor therapy. Tumor immunotherapy exerts antitumor effects through reshaping immune microenvironment, showing significant preclinical advantages. Based on mechanisms immunity activation, agents can be divided into chemotherapeutic agents, immunomodulators, enzymes, vaccines oligonucleotide drugs, etc. Herein, we review MOFs-based drug delivery systems for immunotherapy. The classification MOFs, followed activation mechanisms, first introduced. Drug based with different also summarized, especially synergetic triggered loadings. Furthermore, merits drawbacks strategies promote applications discussed.

Language: Английский

Bifunctional cascaded single-atom nanozymes for enhanced photodynamic immunotherapy through dual-depressing PD-L1 and regulating hypoxia

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123106 - 123106

Published: Jan. 11, 2025

Language: Английский