Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 18, 2025

Aim To develop a glycerol modified liposomes to effectively deliver active agents into posterior segment of the eye for management uveitis.

Language: Английский

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Enhanced chemodynamic porphyrin-modified magnetite nanoagents: A triple-action strategy for potent antimicrobial therapy and wound healing

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 687, P. 742 - 755

Published: Feb. 16, 2025

Language: Английский

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Responsive Microneedles for Diagnostic and Therapeutic Applications of Ocular Diseases

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Traditional ophthalmic formulations are characterized by low bioavailability, short intraocular retention time, strong irritation, and failure to achieve the expected therapeutic effect due special physiological structure of eye existence many barriers. Microneedle drug delivery is a novel transdermal modality. Responsive microneedles defined as controllably releasing payloads in response stimuli, including pH levels, temperature, enzymes, reactive oxygen species (ROS), well external stimuli such magnetic fields light. In addition inheriting advantages traditional microneedles, which include enhanced targeting permeability, non‐invasiveness, painless application, integration with stimulus‐responsive materials enables responsive personalized precision process, further increases accuracy efficiency ocular treatments, making on‐demand possible. This article systematically reviews classification, mechanisms, characteristics provides detailed introduction their diagnostic applications real‐time monitoring potential diseases, aiming offer insights for treatment diseases future.

Language: Английский

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Determination of Prohibited Corticosteroids, Dexamethasone, Prednisolone and Triamcinolone in Cosmetic Creams by Combination of Dispersive Solid Phase Extraction and High-Performance Liquid Chromatography with Diode Array Detection (HPLC-DAD)

Analytical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 20, 2025

Language: Английский

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Pt-Induced Sublattice Distortion Facilitates Enzyme Cascade Reactions for Eradicating Intracellularly Methicillin-Resistant Staphylococcus aureus and Enhancing Diabetic Wound Healing

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Metal oxide nanozymes hold significant potential in combating bacterial infections; however, their ordered crystal structures limit the enhancement of catalytic activity, posing challenges addressing clinical needs for eliminating intracellularly colonized bacteria. Here, we report development an integrated diagnostic-therapeutic microneedle patch incorporates Res@PtZ-Z nanozyme hybrid. consists a ZIF shell loaded with natural compound resveratrol (Res), encapsulating Pt-doped zinc (ZnO) core (PtZ). The Res component modulates charge distribution on and attenuates virulence, thereby promoting uptake by host cells. PtZ core, doped Pt4+ to induce sublattice distortion ZnO, exhibits oxidase-like, peroxidase-like, catalase-like activities. Under intracellular hypoxic conditions, cascade these enzyme-like activities ensures sustained generation reactive oxygen species (ROS), enabling robust antibacterial effects. Additionally, enables real-time infection monitoring oxidizing 3,3',5,5'-tetramethylbenzidine (TMB) substrate produce distinct colorimetric response. This approach addresses both methicillin-resistant Staphylococcus aureus (MRSA) invasion persistence, contributing improved management wound healing.

Language: Английский

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Highly Efficient and Broad-Spectrum Antibacterial Carbon Dots Combat Antibiotic Resistance

Talanta, Journal Year: 2024, Volume and Issue: 281, P. 126926 - 126926

Published: Sept. 19, 2024

Language: Английский

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Intrinsically bioactive multifunctional Poly(citrate-curcumin) for rapid lung injury and MRSA infection therapy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 158 - 173

Published: July 17, 2024

Language: Английский

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Versatile Self-Assembled Near-Infrared SERS Nanoprobes For Multidrug-Resistant Bacterial Infection-Specific Surveillance and Therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Non-viral gene therapy for Leber’s congenital amaurosis: progress and possibilities

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14

Published: Dec. 20, 2024

Leber's congenital amaurosis (LCA) represents a set of rare and pervasive hereditary conditions the retina that cause severe vision loss starting in early childhood. Targeted treatment intervention has become possible thanks to recent advances understanding LCA genetic basis. While viral vectors have shown efficacy gene delivery, they present challenges related safety, low cargo capacity, potential for random genomic integration. Non-viral therapy is safer more flexible alternative treating underlying mutation causing LCA. delivery methods, such as inorganic nanoparticles, polymer-based systems, lipid-based bypass risks immunogenicity integration, potentially offering versatile personalized patients. This review explores background LCA, emphasizing mutations involved, diverse non-viral methods being developed. It also highlights studies on animal models clinical trials. presents future perspectives therapy, including integrating emerging technologies like CRISPR-Cas9, interdisciplinary collaborations, medicine, ethical considerations.

Language: Английский

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A supramolecular hydrogel eye-drop alleviates inflammation via clathrin-mediated endocytosis

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 663, P. 124563 - 124563

Published: Aug. 5, 2024

Language: Английский

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