Fabrication and characterization of calcium peroxide and berberine loaded cryogels for enhanced wound healing DOI
Lateef Ahmad Dar,

Tasaduq Manzoor,

Sabeeha Shafi

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(34), P. 8431 - 8443

Published: Jan. 1, 2024

This study explores cryogels, loaded with CP and berberine BB for wound healing. The cryogels exhibited high porosity, biocompatibility, sustained release of BB. scaffolds accelerated closure improved healing in a rat model.

Language: Английский

Intelligent hydrogel-based dressings for treatment of chronic diabetic wounds DOI
Chenguang Liu,

Li He

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(5)

Published: April 24, 2025

Diabetic wounds represent a significant challenge in the medical field, significantly impacting patient quality of life and imposing heavy burden on healthcare systems. Intelligent hydrogel dressings have attracted attention diabetic wound treatment due to their unique properties. This review systematically explores three main categories intelligent hydrogels (natural, synthetic, composite), dissecting composition, structure, mechanisms that enable responses. The crucial roles these maintaining moist environment, efficiently absorbing exudate, precisely delivering drugs are expounded. Moreover, application advantages combating bacteria infections, regulating inflammation immunity, promoting angiogenesis tissue regeneration, as well enabling real-time monitoring personalized treatment, explored depth. Additionally, we discuss future research directions prospects for precision medicine care, aiming inspire innovation provide comprehensive theoretical basis development next-generation dressings.

Language: Английский

Citations

0
Antibacterial and antioxidant supramolecular nanocomposite hydrogel dressings with angiogenesis and photo-thermal effect for multidrug‐resistant bacterial infected wound healing DOI
Zhenlong Li, Ying Huang,

Jinlong Luo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156381 - 156381

Published: Oct. 1, 2024

Language: Английский

Citations

3
Self-Assembled Ce6-Peptide Nanoparticles Enhance NO Production and Photodynamic Therapy against Bacterial Infections DOI

Miaozhong Shen,

Jing Yan,

Weiyu Xing

et al.

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

The alarming rise of antibiotic resistance necessitates the development innovative antibacterial strategies. Photodynamic therapy (PDT) has emerged as a promising alternative, but its efficacy is often hindered by poor photosensitizer solubility and potential biotoxicity. To overcome these limitations, we designed peptide-photosensitizer conjugate, chlorin e6-RFSSFR (Ce6-RFSSFR), which self-assembles into nanoparticles with improved photodynamic properties. This conjugate leverages arginine residues nitric oxide (NO) donors upon light activation, facilitating localized NO production amplifying effects PDT. Our in vitro vivo evaluations demonstrate superior therapeutic Ce6-RFSSFR over conventional Ce6, enhanced efficacy, remarkable wound healing promotion, anti-inflammatory These findings position candidate for clinical applications bacterial infection treatment tissue regeneration, offering valuable tool fight against antimicrobial resistance.

Language: Английский

Citations

0
A biomimetic endothelial glycocalyx-like hydrogel armored non-glutaraldehyde bioprosthetic valve to resist the thrombosis, calcification and oxidative stress and modulate the immune responses DOI
Lin Chen, Bo Wei, Xueyu Huang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161010 - 161010

Published: Feb. 1, 2025

Language: Английский

Citations

0
Nitric oxide-delivering surface modification for tailoring cell-material interactions on medical device surface: From surface-functionalized design to therapeutic applications DOI
Yihan Sun, Cheng Xiong,

Jun-Yao Yuan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162378 - 162378

Published: April 1, 2025

Language: Английский

Citations

0
Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology DOI
Yiran Wang, Yaqiong Yang, Jiachen Liu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156850 - 156850

Published: Oct. 1, 2024

Language: Английский

Citations

3
Lignin-Based Visible Light-Triggered Nitric Oxide Nanogenerator for Antibacterial Applications DOI
Xiaoya Li, Qian Zhang, Weidong Wu

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Nitric oxide (NO) has received growing attention as an effective antibacterial agent with broad-spectrum activity and a low risk of resistance. However, it remains challenging to develop effective, controllable, biocompatible NO-releasing materials. Here, we report novel NO nanogenerator (AL-BNN6-PEG) self-assembled by lignin, UV-absorbing hydrophobic donor (

Language: Английский

Citations

2
Iron Single-Atom Nanozyme with Inflammation-Suppressing for Inhibiting Multidrug-Resistant Bacterial Infection and Facilitating Wound Healing DOI
Shiwen Chen, Kaiyan Zhang, Chaoxi Chen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(11), P. 7206 - 7216

Published: Oct. 19, 2024

Infection with drug-resistant bacteria and the formation of biofilms are main factors contributing to wound healing insufficiency. Antibacterial agents enzyme-like properties have exhibited considerable potential for efficient eradication microorganisms due their superior sensitivities minimal side effects. In this work, we prepared a kind Fe-centered single-atom nanozyme (Fe-SAzyme) high biocompatibility stability via facile one-pot hydrothermal method, which was suitable treatment wounds infected bacteria. The Fe-SAzyme remarkable peroxidase-like catalytic activities, catalyzing conversion hydrogen peroxide (H2O2) highly toxic hydroxyl radicals (•OH), could not only damage bacterial cells but also inhibit, disrupt, eradicate biofilms. Thus, demonstrated broad-spectrum antibacterial performance capable effectively eliminating multidrug-resistant coexistence ferrous (Fe2+) ferric (Fe3+) ions in conferred anti-inflammatory activity, suppressing excessive inflammation. Meanwhile, significantly downregulate inflammatory cytokines tumor necrosis factor-α interleukin-1β upregulate growth VEGF epidermal factor, can prevent infection, mitigate inflammation, promote fibroblast proliferation, improve closure. had shown favorable therapeutic efficiency promoting bacteria-infected healing. This study provides as promising candidate development new strategies treat infections.

Language: Английский

Citations

1
Combination Strategy of Two Hydrogels Loaded with Prussian Blue Nanoparticles and Calcium Peroxide Separately for Diabetic Wound Repair DOI

Shuo Chai,

Fei Li, Chunxue Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(18), P. 21327 - 21339

Published: Sept. 9, 2024

Language: Английский

Citations

0
Stimuli-responsive hydrogel microspheres encapsulated with tumor-cell-derived microparticles for malignant ascites treatment DOI

Shishi Zhu,

Xin Shou, Gaizhen Kuang

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 192, P. 328 - 339

Published: Nov. 24, 2024

Language: Английский

Citations

0