A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis DOI

Yutian He,

Zhi‐Qiang Liu, Songhang Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58477 - 58488

Published: Oct. 18, 2024

Sepsis is a disease with high morbidity and mortality, for which effective treatments are lacking. In recent years, microRNAs (miRs) have been shown to regulate numerous biological processes can function as therapeutic options various diseases. However, the poor stability cell entry properties of miRs greatly limited their clinical application. this study, we developed tetrahedral framework nucleic acid (tFNA)-based bioswitchable miR delivery system (BiRDS) deliver miR-150 treatment sepsis. BiRDS showed anti-inflammatory effects both in vitro vivo by regulating NF-κB Notch1 pathways. Therefore, holds promise an ideal candidate tackling systemic inflammation multiorgan dysfunction septic patients future.

Language: Английский

A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis DOI

Yutian He,

Zhi‐Qiang Liu, Songhang Li

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58477 - 58488

Published: Oct. 18, 2024

Sepsis is a disease with high morbidity and mortality, for which effective treatments are lacking. In recent years, microRNAs (miRs) have been shown to regulate numerous biological processes can function as therapeutic options various diseases. However, the poor stability cell entry properties of miRs greatly limited their clinical application. this study, we developed tetrahedral framework nucleic acid (tFNA)-based bioswitchable miR delivery system (BiRDS) deliver miR-150 treatment sepsis. BiRDS showed anti-inflammatory effects both in vitro vivo by regulating NF-κB Notch1 pathways. Therefore, holds promise an ideal candidate tackling systemic inflammation multiorgan dysfunction septic patients future.

Language: Английский

Citations

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