Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy DOI Creative Commons
Ting Yang, Zihan Liu,

Zixuan Fu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100970 - 100970

Published: Oct. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Language: Английский

Inherently Anti-Metastatic Peptide Hydrogels for Sonodynamic-Amplified Ferroptosis in Cancer Therapy DOI Creative Commons
Hongxia Zhang, Yamei Wang, Mengmeng Jiang

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101688 - 101688

Published: March 1, 2025

Language: Английский

Citations

0
Engineering Dual-Responsive Nanoplatform Achieves Copper Metabolism Disruption and Glutathione Consumption to Provoke Cuproptosis/Ferroptosis/Apoptosis for Cancer Therapy DOI

Meiru Zhang,

Hui Xu,

Xiaozan Wu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Cuproptosis is a new copper-dependent form of regulated cell death and shows enormous promise in cancer therapy. However, its therapeutic performance compromised by the strictly copper metabolism highly expressed intracellular glutathione (GSH). Herein, an intelligent nanoplatform (NSeMON-P@CuT/LipD) rationally developed as metabolic disrupter, GSH consumer, Fenton-like reaction trigger for cuproptosis/ferroptosis/apoptosis NSeMON-P@CuT/LipD constructed from preparation diselenide-bridged mesoporous organosilica nanoparticles, then pemetrexed (Pem) loaded followed surface deposition with Cu2+-3,3′-dithiobis(propionohydrazide) (TPH) coordinated network coating diclofenac (DC)-encapsulated liposome. In response to specific tumor microenvironment, obtained can release DC, Cu2+, Pem simultaneously amplify cellular oxidative stress consuming catalyzing endogenous H2O2 into hydroxyl radicals (•OH). Both liberated DC augmented inhibit glycolysis, reduce ATP level, block transporter ATP7B, resulting disorders high retention cells •OH generation. Moreover, overloaded promote dihydrolipoamide S-acetyltransferase oligomerization Fe–S cluster protein loss, thus evoking cuproptosis. Collectively, activates prominent ferroptosis, which cooperates cuproptosis Pem-mediated apoptosis significantly growth 4T1 tumor-bearing mice. This study demonstrates feasible strategies enhance using single may also inspire design advanced cuproptosis-related therapies.

Language: Английский

Citations

0
Enhanced Anticancer Efficacy of Alkaline Plasma-Activated Water through Augmented RONS Production DOI

Bolun Pang,

Zhijie Liu, Yuting Gao

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 467 - 483

Published: Dec. 18, 2024

Despite notable advances in anticancer drug development, their manufacture and use pose environmental health risks due to toxic byproducts, residue contamination, cytotoxicity normal cells. Therefore, developing cost-effective treatments with fewer side effects higher selectivity is essential the advancement of highly effective therapies. Plasma-activated water (PAW) offers a green alternative conventional chemical as it reverts within days. However, limited duration dose reactive oxygen nitrogen species (RONS) acidified PAW restrict its clinical deployment full understanding mechanism. In this study, we propose alkaline an innovative enhancement RONS technology. The generated markedly superior RONS, about 10 times levels NO2–, H2O2, ONOO–/O2•– than acidic PAW. possible generation pathways are analyzed by scavengers. PAW, 70% H2O2 concentration contributed •OH but only 20% ONOO– mainly formed through reaction O2•– NO pH, while forms from NO2– H2O2. results unveiled synergistic formidable against cancer cells, typified increase intracellular ROS/RNS levels. Furthermore, injection also effectively prevented xenograft tumor growth mice. We systematically investigated high-dose solution without using noble gases, reagents, or extra energy consumption successfully demonstrated possibility being environmentally friendly therapeutic activity closely linked dose, pathway provides much-needed insight into fundamental aspects chemistry required for optimization biochemical

Language: Английский

Citations

1
Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+ T cells for triple-negative breast cancer therapy DOI Creative Commons
Ting Yang, Zihan Liu,

Zixuan Fu

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 100970 - 100970

Published: Oct. 1, 2024

Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of antioxidant system resulting from iron accumulation in triple-negative breast cancer (TNBC) therapy. However, ferroptosis accompanied with down-regulation glutathione peroxidase 4 (GPX4) lead to CD36-mediated tumor-infiltrating CD8+ T cells uptaking fatty acids, negative action on immunotherapeutic efficacy. Herein, albumin nanoparticles, abbreviated LHS NPs, were designed by co-assembly hemin, linoleic acid-cystamine, CD36 inhibitor sulfosuccinimide oleate, bi-directionally manipulated tumor TNBC NPs exerted more efficient reactive oxygen species generation, depletion malondialdehyde production combinatory classical non-classical modes, which amplified positive cells. Meanwhile, inhibiting mediated-lipid cells, thereby activating efficacy improvements induction immunogenic death, proliferation CD4+CD8+ natural killer alleviation immunosuppressive regulatory myeloid-derived suppressor repolarization M2- M1-phenotype tumor-associated macrophages. Thus, demonstrated an improved antitumor suppressing growth lung metastasis 4T1-tumor mice. Our work gives novel insights manipulating chemoimmunotherapy.

Language: Английский

Citations

0