Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 16, 2024
The
cGAS-STING
signaling
pathway
is
a
critical
component
of
the
innate
immune
response,
playing
significant
role
in
various
diseases.
As
central
element
this
pathway,
STING
responds
to
both
endogenous
and
exogenous
DNA
stimuli,
triggering
production
interferons
pro-inflammatory
cytokines
enhance
defenses
against
tumors
pathogens.
However,
dysregulated
activation
implicated
pathogenesis
multiple
diseases,
including
autoinflammation,
viral
infections,
cancer.
Traditional
Chinese
Medicines
(TCMs),
which
have
long
history
use,
been
associated
with
positive
effects
disease
prevention
treatment.
TCM
formulations
(e.g.,
Lingguizhugan
Decoction,
Yi-Shen-Xie-Zhuo
formula)
active
compounds
Glabridin,
Ginsenoside
Rd)
can
modulate
thereby
influencing
progression
inflammatory,
infectious,
or
oncological
This
review
explores
mechanisms
by
TCMs
interact
regulate
immunity,
focusing
on
their
roles
infectious
malignancies,
autoimmune
disorders.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(6), P. 1345 - 1345
Published: March 17, 2025
Reactive
oxygen
species
play
a
significant
role
in
various
pathological
conditions,
driving
the
need
for
novel,
potent
antioxidants.
While
polyphenols
are
known
their
antioxidant
properties,
limited
stability
and
bioavailability
present
challenges
therapeutic
applications.
To
address
these
limitations,
series
of
novel
thiazolyl-polyphenolic
compounds
was
synthesized
via
multi-step
synthetic
route
incorporating
Hantzsch
heterocyclization
final
step.
The
7a–k
were
structurally
characterized
using
spectroscopic
techniques,
including
NMR,
MS,
IR.
In
silico
thermodynamic
calculations,
HOMO–LUMO
gap
bond
dissociation
enthalpy
(BDE)
revealed
promising
profile
indicated
that
substitution
position
2
thiazole
ring
does
not
substantially
influence
activity
conferred
by
catechol
moiety
4.
capacity
experimentally
validated
panel
six
distinct
assays:
two
radical
scavenging
assays
(ABTS
DPPH)
four
electron
transfer-based
(RP,
TAC,
FRAP,
CUPRAC).
vitro
evaluation
demonstrated
7j
7k
exhibited
significantly
enhanced
compared
to
established
standards,
ascorbic
acid
Trolox.
These
findings
suggest
strategic
modifications
scaffold
represent
direction
future
research
aimed
at
developing
agents
with
properties.
study
is
based
on
N-methyl
substituted
scaffold,
but
studies
can
include
such
as
changing
substituent
nitrogen,
hydrazone
linker
or
possible
insertion
substituents
5
electronic
physico-chemical
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Mercury
ion
(Hg2+),
a
prevalent
heavy
metal,
is
commonly
found
in
environmental
soil
and
water.
Its
interaction
with
sulfhydryl
groups
proteins
or
lipids
can
cause
oxidative
stress
disrupt
calcium
homeostasis.
This
leads
to
severe
health
issues,
including
digestive,
nervous,
immune
system
damage.
Conventional
Hg2+
detection
methods,
such
as
ICP-MS
AAS,
require
complex
procedures
bulky
instruments,
limiting
their
applicability
for
real-time,
on-site
analysis.
AI-assisted
methods
have
emerged
promising
solutions,
offering
portability
rapid
capabilities.
Deep
eutectic
solvents
(DESs),
particularly
hydrophobic
DESs
(HDESs),
provide
an
environmentally
friendly
alternative
enriching
detecting
metal
ions.
study
aims
develop
portable,
cost-effective,
colorimetric
sensing
platform
based
on
silver
nanoparticles
deep
(AgNPs-HDES)
enrichment
detection.
AgNPs-HDES
was
synthesized
using
ethylene
glycol
containing
(AgNPs-EG)
the
hydrogen
bond
donor.
Electrostatic
potential
maps
(ESP)
density
functional
theory
(DFT)
were
employed
elucidate
its
synthesis
mechanisms.
Smartphone
image
acquisition
combined
YOLOv8-based
AI
software
enabled
high-throughput
analysis
A
progressive
color
change
from
brownish-yellow
colorless
observed
concentration
increased,
eliminating
hydrophilic
interference
improving
sensitivity.
The
demonstrated
linear
range
of
1-40
μmol·L-1
(R2
=
0.9889)
limit
0.23
μmol·L-1.
Recovery
rates
real
samples,
lake
water,
soil,
seawater
industrial
sewage,
ranged
90.3
%
123
%.
established
enables
rapid,
highly
accurate
across
multiple
samples
simultaneously.
AI-assisted,
presents
valuable
tool
monitoring
pollutant
tracking.
