Addition of bioglass particles to flexible polyvinyl alcohol–chitosan hydrogel films strengthens their mechanical properties and osteoblast cell activity DOI
Tzer-Min Lee,

Ken‐Chung Chen,

Yu-Chen Lu

et al.

Emergent Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

Citations

1
Injectable hydrogels with ROS-triggered drug release enable the co-delivery of antibacterial agent and anti-inflammatory nanoparticle for periodontitis treatment DOI Creative Commons

Yujing Zhu,

Z.Y. Xiu,

Xingyu Jiang

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 12, 2025

Periodontitis, a chronic inflammatory disease caused by bacteria, is characterized localized reactive oxygen species (ROS) accumulation, leading to an response, which in turn leads the destruction of periodontal supporting tissues. Therefore, antibacterial, scavenging ROS, reducing regulating microenvironment, and alleviating alveolar bone resorption are effective methods treat periodontitis. In this study, we developed ROS-responsive injectable hydrogel modifying hyaluronic acid with 3-amino phenylboronic (PBA) reacting it poly(vinyl alcohol) (PVA) form borate bond. addition, encapsulated antibacterial agent minocycline hydrochloride (MH) Fe-Quercetin anti-inflammatory nanoparticles (Fe-Que NPs) for on-demand drug release response periodontitis microenvironment. This (HP-PVA@MH/Fe-Que) exhibited highly properties. Moreover, modulating Nrf2/NF-κB pathway, effectively eliminated ROS promoted macrophage polarization M2 phenotype, inflammation enhancing osteogenic differentiation potential human ligament stem cells (hPDLSCs) Animal studies showed that HP-PVA@MH/Fe-Que significantly reduced loss enhanced factor expression killing bacteria inhibiting inflammation. Thus, had efficient ROS-scavenging, anti-inflammatory, resorption-alleviation abilities, showing excellent application healing.

Language: Английский

Citations

0
Customized Hydrogel System for the Spatiotemporal Sequential Treatment of Periodontitis Propelled by ZEB1 DOI Creative Commons
Jiafei Chen, Xiaoxu Guan, Lina Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Advanced periodontitis initiates with Porphyromonas gingivalis ( P. ) infection, which subsequently triggers chronic inflammation, immune imbalance, and ultimately causes alveolar bone resorption. Traditional periodontal treatment focuses on the elimination of triggering factors, but tend to ignore improvement inflammatory microenvironment remodeling osteogenic mineralization space. Herein, zinc‐aluminum layered double hydroxide nanosheets (LDHs) loaded icariin (ICA) are encapsulated into a gallic acid (GA)‐modified hydroxybutyl chitosan hydrogel (GA‐HBC), giving rise customized system named GA‐HBC‐LIC, can sequentially actualize antibacterial, anti‐inflammatory, remineralization functions. A neutral chemical‐humoral space is created for osteogenesis via means sequential regulation by smart hydrogel. Concomitantly, appropriate mechanical properties degradation performance provide desirable physical remineralization. In spatiotemporal modulation hydrogel, zinc finger E‐box‐binding homeobox 1 (ZEB1) target released ions (Zn 2+ action promotes macrophage polarization from M1 M2 phenotype, thereby releasing cytokines conducive tissue regeneration. sum, this study highlights critical role inflammation maintenance in regeneration tissues, offering new insights clinical management periodontitis.

Language: Английский

Citations

0
DNAzyme-driven Z-scheme g-C3N4/V2C heterojunction reactivation for photoelectrochemical assessment of bacterial viability DOI
Yi Deng,

Shuqi Quan,

Erkang Tian

et al.

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117503 - 117503

Published: April 1, 2025

Language: Английский

Citations

0
Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis DOI

Ziyi Xu,

Yue Wang,

Shuoshun Li

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 175, P. 214326 - 214326

Published: April 27, 2025

Language: Английский

Citations

0
Addition of bioglass particles to flexible polyvinyl alcohol–chitosan hydrogel films strengthens their mechanical properties and osteoblast cell activity DOI
Tzer-Min Lee,

Ken‐Chung Chen,

Yu-Chen Lu

et al.

Emergent Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

Citations

0