Sustainable keratoplasty models using agri-food waste: a hypothesis for transforming biowaste into biomaterials for tissue engineering research

Frontiers in Sustainable Food Systems, Journal Year: 2025, Volume and Issue: 9

Published: March 26, 2025

With a growing global population, ways to counterbalance the demand for meat products with effective food security and waste management innovative scalable solutions. Concurrently, alarming incidence of end-stage organ failure, limited availability transplantable organs, directives reduce reliance on animal testing underscore need clinically viable sustainable alternatives. Our approach introduces hypothesis-driven, renewable tissue engineering strategy that creates low-cost keratoplasty models derived entirely from agri-food waste. Specifically, we hypothesize abundant by-products, such as eyes bladders, provide practically unlimited readily available supplies corneal tissues urine-derived stem cells (USCs) can be repurposed into cost-effective, relevant Traditional approaches often rely cadaveric tissues, invasive cell sourcing, or expensive commercial lines, which require complex resource-intensive processes, including high-end bioreactor systems manufacturing environments. These requirements limit widespread adoption technological progress needed increase supply keratografts. proposed leverages combination post-mortem bladder harvesting, in turn facilitates decellularization, non-invasive USC differentiation, compartment-specific recellularization help overcome barriers associated traditional seeding generate this type Overall, our perspective suggests way devise transformative resource-efficient engineering, specifically geared toward improving outcomes while offering broader applications regeneration other bodily tissues/organs biotechnological innovation.

Language: Английский

---

New Dawn in the Treatment of Rheumatoid Arthritis: Advanced Insight into Polymer Hydrogel Research

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 136 - 136

Published: Feb. 15, 2025

As a chronic systemic autoimmune disease, rheumatoid arthritis (RA) not only damages joints and other organs or systems throughout the body but also torments patients' physical mental health for long time, seriously affecting their quality of life. According to incomplete statistics at present, global prevalence RA is approximately 0.5-1%, number patients increasing year by year. Currently, drug therapies are usually adopted treatment RA, such as non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic (DMARDs), glucocorticoids/steroids, so on. However, traditional therapy has problems half-lives, cycles requiring frequent administration, lack specificity, possible adverse reactions (such gastrointestinal side effects, skin stratum corneum barrier damage, toxicity), which greatly restrict RA. In order improve limitations drug, physical, surgical treatments large related studies on have been carried out. Among them, hydrogels widely used in research due excellent biocompatibility, mechanical properties, general adaptability. For example, can be injected into synovial cavity fluid reduce wear between joints, lubricate avoid surface degradation. This article reviews applications under different functions situation carriers through delivery routes confirms outstanding potential great significance.

Language: Английский

---

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Biomaterials, Journal Year: 2025, Volume and Issue: 320, P. 123270 - 123270

Published: March 22, 2025

Recapitulating the biophysical and biochemical complexity of extracellular matrix (ECM) remains a major challenge in tissue engineering. Hydrogels derived from decellularized ECM provide unique opportunity to replicate architecture bioactivity native ECM, however, they exhibit limited long-term stability mechanical integrity. In turn, materials assembled through supramolecular interactions have achieved considerable success replicating dynamic properties ECM. Here, we merge both methodologies by promoting assembly human amniotic membrane (hAM), mediated host-guest between hAM proteins acryloyl-β-cyclodextrin (AcβCD). Photopolymerization cyclodextrins results formation soft hydrogels that tunable stress relaxation strain-stiffening. Disaggregation bulk yields an injectable granular material self-reconstitutes into shape-adaptable hydrogels, supporting cell delivery neovascularization. Additionally, cells encapsulated within sense respond surrounding matrix, as early spreading is favored greater susceptibility applied stress, evidencing proper cell-matrix interplay. Thus, this system shown be promising substitute for repair modelling.

Language: Английский

---

Injectable acellular matrix microgel assembly with stem cell recruitment and chondrogenic differentiation functions promotes microfracture-based articular cartilage regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 44, P. 220 - 235

Published: Oct. 19, 2024

Language: Английский

---

Decellularized Extracellular Matrix Scaffolds: Recent Advances and Emerging Strategies in Bone Tissue Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Bone tissue engineering (BTE) is a complex biological process involving the repair of bone with proper neuronal network and vasculature as well surrounding soft tissue. Synthetic biomaterials used for BTE should be biocompatible, support regeneration, eventually degraded in situ replaced newly generated Recently, various forms graft materials such hydrogel, nanofiber scaffolds, 3D printed composite scaffolds have been developed application. Decellularized extracellular matrix (DECM), kind natural material obtained from specific tissues organs, has certain advantages over synthetic exogenous biomaterial-derived grafts. Moreover, DECM can wide range sources possesses strong molding abilities, structures, bioactive factors. Although shown robust osteogenic, proangiogenic, immunomodulatory, defect healing potential, rapid degradation limited mechanical properties improved bench-to-bed translation BTE. This review summarizes recent advances DECM-based discusses emerging strategies

Language: Английский

---