Unlocking the Potential of Antimicrobial Peptides: Cutting-Edge Advances and Therapeutic Potential in Combating Bacterial Keratitis

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Bacterial keratitis is a prevalent, and severe corneal illness resulting from bacterial pathogens. Failure to administer timely suitable therapy may lead opacity, ulceration, significant vision impairment, or potential blindness. Current clinical interventions for involve the administration of topical antimicrobial agents systemic antibiotics. However, misuse overuse antibiotics have led rapid emergence antibiotic-resistant bacteria. Additionally, restricted antibacterial spectrum possible adverse effects provided considerable obstacles traditional therapies. This highlights urgent need novel highly effective agents. Antimicrobial peptides (AMPs) are class naturally occurring synthetically designed small molecules that gained attention due their unique mechanisms low risk resistance development. AMPs exhibit promising in treating through direct mechanisms, such as inhibiting cell wall synthesis, disrupting membranes, interfering with nucleic acid metabolism, well indirect including modulation host immune response. review provides comprehensive overview advancements treatment keratitis. It emphasizes role various modification strategies artificial-intelligence-assisted design enhancing efficacy, stability, biocompatibility AMPs. Furthermore, this discusses latest progress combining delivery systems improved therapeutic outcomes. Finally, current challenges future perspectives treatment, providing valuable insights developing high safety

Language: Английский

---

An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Microbial keratitis, a sight-threatening corneal infection, remains significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occurrence of resistance, with prognosis. Novel treatment techniques, their unique properties targeted delivery capabilities, offers promising solution to overcome these challenges. This review delves into timely update the state-of-the-art advance therapeutics for keratitis treatment. The diverse microbial origins including viral, bacterial, fungal infections, exploring complex pathogenic mechanisms, followed by resistance mechanisms in pathogens are reviewed briefly. Importantly, emerging therapeutic techniques piezodynamic therapy, photothermal photodynamic nanoenzyme metal ion therapy summarized this showcasing potential traditional treatments. challenges future directions nanotechnology-based approaches discussed, focusing on safety, targeting strategies, combination therapies. aims inspire researchers revolutionize accelerate development functional materials different

Language: Английский

---

Near-Infrared-Light-Enhanced Ultrasmall Ruthenium Dioxide Nanozyme against Drug-Resistance Bacterial Infections

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

---

Stimuli-responsive and targeted nanomaterials: Revolutionizing the treatment of bacterial infections

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 495 - 523

Published: Nov. 29, 2024

Language: Английский

---