Continuous Valorization of Carbon Dioxide into the Fine Chemical Ectoine by Hydrogenovibrio marinus: A New Strategy for Pharmaceutical Production DOI
Elisa Huang-Lin, Raquel Lebrero, Sara Cantera

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Current challenges in biopharmaceutical manufacturing, such as ectoine production, include high operational costs and limited availability. Transitioning to processes that valorize renewable carbon sources like CO2 into can make production more sustainable accessible the economy society. However, cell platforms produce with still require bioprocess optimization resilient microorganisms able continuously maintain yields removals. A comprehensive screening of cultivation strategies was conducted six stirred-tank gas bioreactors using strain Hydrogenovibrio marinus, a halophilic, fast-growing, hydrogenotrophic bacterium low nutrient requirements. Gas residence times 120 min at ratios 10:40:50 CO2:H2:air (% v/v) dilution rates 0.25 d-1 boosted biomass growth during long-term operation. Under these conditions, productivity reached 5.0 ± 0.3 g m-3 d-1, maximum specific contents 134.0 6.3 mgEct gbiomass-1, achieving similar heterotrophic strains. This study demonstrates for first time feasibility integrating continuous abatement H2 clean hazard-free energy source, which marks significant advancement manufacturing circularity.

Language: Английский

Continuous Valorization of Carbon Dioxide into the Fine Chemical Ectoine by Hydrogenovibrio marinus: A New Strategy for Pharmaceutical Production DOI
Elisa Huang-Lin, Raquel Lebrero, Sara Cantera

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Current challenges in biopharmaceutical manufacturing, such as ectoine production, include high operational costs and limited availability. Transitioning to processes that valorize renewable carbon sources like CO2 into can make production more sustainable accessible the economy society. However, cell platforms produce with still require bioprocess optimization resilient microorganisms able continuously maintain yields removals. A comprehensive screening of cultivation strategies was conducted six stirred-tank gas bioreactors using strain Hydrogenovibrio marinus, a halophilic, fast-growing, hydrogenotrophic bacterium low nutrient requirements. Gas residence times 120 min at ratios 10:40:50 CO2:H2:air (% v/v) dilution rates 0.25 d-1 boosted biomass growth during long-term operation. Under these conditions, productivity reached 5.0 ± 0.3 g m-3 d-1, maximum specific contents 134.0 6.3 mgEct gbiomass-1, achieving similar heterotrophic strains. This study demonstrates for first time feasibility integrating continuous abatement H2 clean hazard-free energy source, which marks significant advancement manufacturing circularity.

Language: Английский

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