Liposome‐Based Interventions in Knee Osteoarthritis DOI Creative Commons
Evgenia Mitsou, Jacob Klein

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Osteoarthritis (OA) is the most common degenerative disease of joints, causing significant disability and socio-economic burden in aging population. Simultaneously, however, it a occurrence younger individuals, initiated by joint injuries or obesity alongside other factors. Intravenous oral pharmaceutical OA management have both been associated with systemic adverse effects, thereby resulting growing interest intra-articular (IA) treatment. IA-administered drugs circumvent requirement for high dosage, offering immediate access to site while minimizing any unfavorable effects. Nonetheless, IA-injected drugs, administered their free form, present low retention time knee raising need multiple injection dosage regimens, capability target cartilage specific cell populations limited. Liposomes, due unique characteristics tunable nature, proven be excellent candidates OA. This review explores last decade's research on efficacy various IA liposomal formulations, investigating multifaceted properties as carriers, lubricating agents, basis combinatorial approaches paving way novel treatment solutions

Language: Английский

Lubrication for Osteoarthritis: From Single-Function to Multifunctional Lubricants DOI Open Access
Wen Chen, Qianwen Ye,

Mingshuo Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1856 - 1856

Published: Feb. 21, 2025

Osteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for treatment are reviewed both single-function multifunctional lubricants. Single-function mainly include glycosaminoglycans, lubricin, phospholipids, whereas composed anti-inflammatory bifunctional hydrogels, stem cell-loaded drug-loaded nanoparticles. This review emphasizes importance lubrication capacity explores structural features, properties, role these modulating intracellular inflammatory responses metabolism. Current challenges future research directions field also discussed, with aim providing scientific basis new ideas clinical OA.

Language: Английский

Citations

0
Liposome‐Based Interventions in Knee Osteoarthritis DOI Creative Commons
Evgenia Mitsou, Jacob Klein

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Osteoarthritis (OA) is the most common degenerative disease of joints, causing significant disability and socio-economic burden in aging population. Simultaneously, however, it a occurrence younger individuals, initiated by joint injuries or obesity alongside other factors. Intravenous oral pharmaceutical OA management have both been associated with systemic adverse effects, thereby resulting growing interest intra-articular (IA) treatment. IA-administered drugs circumvent requirement for high dosage, offering immediate access to site while minimizing any unfavorable effects. Nonetheless, IA-injected drugs, administered their free form, present low retention time knee raising need multiple injection dosage regimens, capability target cartilage specific cell populations limited. Liposomes, due unique characteristics tunable nature, proven be excellent candidates OA. This review explores last decade's research on efficacy various IA liposomal formulations, investigating multifaceted properties as carriers, lubricating agents, basis combinatorial approaches paving way novel treatment solutions

Language: Английский

Citations

0