Dynamic Hyaluronic Acid Hydrogels for Comprehensively Regulating Inflammation, Angiogenesis, and Metabolism to Effectively Proheal Diabetic Wounds

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(51), P. 70256 - 70273

Published: Dec. 13, 2024

Despite the great progress of various multifunctional wound dressings, it is challenging to simultaneously achieve complete healing and functional remodeling for diabetic foot ulcers refractory chronic wounds. Aiming comprehensively regulate inflammation, angiogenesis, metabolism processes, herein, a novel kind dynamic hyaluronic acid (HA) hydrogel was designed by combining boronate coordination chemistry. Besides having injectability, self-healing, detachment properties, HA hydrogels presented wound-responsive degradation controllable H2S release. They could efficiently polarize M1-to-M2 polarization inflammatory cytokine secretion multiple inflammation-related mRNA expressions through cooperative actions reactive oxygen species elimination + release Zn2+ regulation, thus driving inflammation into proliferation stages. Moreover, screened lead HTZS angiogenesis-related signaling pathways processes promote neovascularization mature vessel formation, re-epithelization, high-level collagen-I deposition, dense hair follicle regeneration, achieving in Importantly, this work opens new avenue design biopolymer high-performance dressing decipher key role orchestrated regulations inflammation–angiogenesis–metabolism on

Language: Английский

Bioenergetic-active photoluminescent bioactive Nanodressing for proangiogenic MRSA infected wound repair and microenviroment monitoring

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156557 - 156557

Published: Oct. 9, 2024

Language: Английский