An Oral H2S Responsive Cu5.4O Nanozyme Platform with Strong ROS/H2S Scavenging Capacity for the Treatment of Colitis DOI
Ma Ying, Yixing Tu, Yang Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 617 - 631

Published: Dec. 25, 2024

Inflammatory bowel disease involves excess reactive oxygen species (ROS) and hydrogen sulfide (H2S) at inflammatory sites. Nanozyme-mediated ROS H2S scavenging therapy is promising for colitis treatment. Here, we synthesized a multiple Cu5.4O nanoparticle first explored its capacity. Chitosan oligosaccharide modified with alpha-lipoic acid was coated on the nanoparticles to further enhance Furthermore, calcium alginate surface develop an oral nanoplatform (Cu5.4O@SAG) possessing dual-pH/H2S-responsive release characteristics. Importantly, Cu5.4O@SAG exhibited enrichment colonic inflammation site relieved index, containing recovery of colon length, spleen liver body weight, as well cell infiltration. In vivo in vitro experiments revealed dual capacities nanoplatform. Additionally, regulated tight junctions, mucus layers, gut microbiota, which accompanied by downregulation cytokines. Notably, also had excellent biocompatibility. conclusion, this multiple-scavenging nanozyme platform provides new safe paradigm development nanozymes

Language: Английский

Incorporating zinc coordination driven nanozyme into chitosan and hyaluronic acid based nanoplatform for scavenging H2S/ROS in managing inflammatory bowel disease DOI
Jiafeng Zou, Wenxing Ding, You Chen

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: unknown, P. 123501 - 123501

Published: March 1, 2025

Language: Английский

Citations

0
Advancing gut microbiome insights: Graphene quantum dot nanobiosensors for microbial metabolite detection DOI
Soheil Sadr, Shakiba Nazemian, Shiva Dianaty

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162954 - 162954

Published: April 1, 2025

Citations

0
An Oral H2S Responsive Cu5.4O Nanozyme Platform with Strong ROS/H2S Scavenging Capacity for the Treatment of Colitis DOI
Ma Ying, Yixing Tu, Yang Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 617 - 631

Published: Dec. 25, 2024

Inflammatory bowel disease involves excess reactive oxygen species (ROS) and hydrogen sulfide (H2S) at inflammatory sites. Nanozyme-mediated ROS H2S scavenging therapy is promising for colitis treatment. Here, we synthesized a multiple Cu5.4O nanoparticle first explored its capacity. Chitosan oligosaccharide modified with alpha-lipoic acid was coated on the nanoparticles to further enhance Furthermore, calcium alginate surface develop an oral nanoplatform (Cu5.4O@SAG) possessing dual-pH/H2S-responsive release characteristics. Importantly, Cu5.4O@SAG exhibited enrichment colonic inflammation site relieved index, containing recovery of colon length, spleen liver body weight, as well cell infiltration. In vivo in vitro experiments revealed dual capacities nanoplatform. Additionally, regulated tight junctions, mucus layers, gut microbiota, which accompanied by downregulation cytokines. Notably, also had excellent biocompatibility. conclusion, this multiple-scavenging nanozyme platform provides new safe paradigm development nanozymes

Language: Английский

Citations

1